Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Institut National De La Sante Et De La Recherche Medicale

Pasteur Merieux Serums, Et Vaccins S.a.

Mark Achtman

Jean-Louis Ruelle

Xavier Nassif

Monique Moreau

Colin Tinsley

Silke Klee

Petra Merker

Carla Vinals

The invention provides novel(Nm) polypeptides and polynucleotides which cover the Nm genetic diversity, and which correspond to polypeptide of Nm outer membrane and/or periplasma, and to methods for producing such Nm compounds. Also provided are anti-Nm infection, and particularly diagnostic. prophylactic and therapeutic uses thereof.

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The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1, beginning with the amino acid in any one of positions 1 to 5 and ending with an amino acid in any one of positions 40 to 104 or a homologous sequence, its use as a carrier for a conjugate, particularly in combination with a polysaccharide, and a process for producing the peptide as well as vaccines comprising said peptide.

IgA1 protease fragment as carrier peptides

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Berlin, Germany

Mark Achtman