Sunovion Pharmaceuticals Inc.

Sepracor, Inc.

Mark A Varney

Liming Shao

Michael Charles Hewitt

Jianguo Ma

Fengjiang Wang

Una Campbell

Scott C Malcolm

Larry Wendell Hardy

Patrick Koch

Sharon Rae Engel

Larry R Bush

Kerry Leigh Spear

Scott Christopher Malcolm

John Emmerson Campbell

Rudy Schreiber

Seth Ribe

Roger P Bakale

Michele L R Heffernan

Seth C Hopkins

H Scott Wilkinson

Robert J Foglesong

Zhengxu Han

Thomas Wessel

Judy Caron

Surendra Singh

Stefan G Koenig

Mustapha Soukri

Steven W Jones

Xiping Su

Karim Lalji

John E Campell

Stephan G Koenig

Surendra P Singh

The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

Cycloalkylamines as monoamine reuptake inhibitors

Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors

One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.

Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine

The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.

Tetralone-based monoamine reuptake inhibitors

This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CRand N. X and Y are members independently selected from O, S, CR, N and NH. R, Rand Rare members independently selected from H and F, provided that at least one member selected from R, Rand Ris F. Ris a member selected from OXand OH, wherein Xis a positive ion, which is a member selected from inorganic positive ions and organic positive ions.

Fluoro-substituted inhibitors of D-amino acid oxidase

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Laguna Niguel, CA, United States of America

Mark A Varney