Biokit, S.a.

Becton Dickinson and Company Limited

Gen-probe, Inc.

Abbott Molecular Inc.

Biomerieux, Inc.

Brooks Automation Gmbh

Siemens Healthcare Diagnostics Gmbh

Persimmon Technologies Corporation

Instrumentation Laboratory Company

Abbott Laboratories Corporation

Mark A Talmer

Paul C Dahlstrom

Gerard J Sevigny

Gerhardt P Schroeder

Dwight Livingston

Jason E Bryant

Timothy Roy Hansen

Gus G Tseo

Scott D Collins

Jared Ian Bullock

Kevin Bailey

Robert C Aviles

Matthew W Webb

Eric Yeaton

Joseph P Skinner

Derek Verhoorn

Thomas D Haubert

Tong Zhou

M Scott Ulrich

Artis R Lockhart

Steven J Allen

Randy J Somerville

Gary P Schroeder

Byron J Knight

Robert Andrew Howard

Robert L Campbell

James A Prescott

Michael L Marshall

Gregory S Kramer

Andrea Liebmann-Vinson

Kevin G Dolan

Jack H Kessler

Ammon David Lentz

Timothy P Henning

Michael Justin Lizzi

Arthur G Sandoval

Scott Nicholas Danhof

Melody M H Kuroda

Chadwick M Dunn

Sonal Sadaria Nana

Kathleen Vincent

Luis Miguel Garcia Gros

Wesley W Addison, Ii

Donald E Gorelick

Timothy J Patno

Dan O'Sullivan

Ian MacGregor

Spencer Lovette

Daniel J Harris

Jody L Keck

Frank Pawlowski

Ernie Ritchey

Miroslaw Bartkowiak

Brett W Johnson

Wendy Dale Woodley

Andre Scherz

Christopher M Embres

Jose Serra Domènech

Kathleen Limerick

David M Peters

Daniel P Casazza

Dan Harris

Josiah Hackendorf

Scott N Danhof

Jack Kessler

Robert F Scalese

Adam C Curry

Kristin Weidemaier

Eric Fallows

David S Sebba

Erin Gooch Carruthers

Rommel M Hipolito

Kavankumar B Patel

Paul M Grippo

Jeffrey S Ojala

Austin Lines

Luis-Miguel Garcia Gros

Melody MH Kuroda

Eric A Fallows

Jose Serra DOMÈNECH

Paul Dahlstrom

Wesley W Addison Ii

David S Sebra

Melody Mh Kuroda

A segmented stator for an electric motor comprises: a plurality of tooth segments arranged in a circular configuration, the tooth segments having body portions and front surfaces extending inward from the body portions; and wire wound on the body portions. A distance between adjacently positioned front surfaces of the tooth segments is less than a width of the wire. The wire wound on the body portions substantially fills space between adjacently positioned tooth segments.

Needle winding for high density copper fill internal tooth electric motor stator and method therefor

Aspects of the present disclosure include sample analysis methods and systems. According to certain embodiments, provided are methods of analyzing samples in an automated sample analysis system. The methods include introducing samples and sample preparation cartridges into the system, isolating and purifying an analyte (e.g., nucleic acids and/or proteins) present in the samples at a sample preparation station, and performing analyte detection assays in assay mixtures that include the purified analyte. Also provided are automated sample analysis systems that find use, e.g., in performing the methods of the present disclosure. In certain aspects, the methods and systems provide for continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids, reagents, commodities, waste, and/or the like.

Systems and methods for automated analysis

This instant disclosure provides methods of processing a sample in an automated sample processing device including devices configured for the automated extraction or isolation of nucleic acids. Also provided are plungers for use in such devices and methods of sample processing. Systems for performing the described methods and employing the described plungers are also provided.

Sample processing devices, systems and methods

Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.

Rotary platform for cell lysing and purification and method of use

Slide analysis a gripper with three sensors for controlling a slide grip sequence and at least one rotatable carousel with a slide receiving channel. The systems also include a robot with a robot arm that holds a slide gripper residing inside the housing in communication with the rotatable carousel. The systems also include a load lock chamber and a door sealably coupled to the second end portion and an acquisition vacuum chamber with an X-Y stage and a slide holder with a vacuum seal.

Sample handling systems, mass spectrometers and related methods

Embodiments of the invention relate to a clinical instrument analyzer system for the automatic analysis of patient samples. In one embodiment, the analyzer may be used to analyze bodily fluid samples, such as blood, plasma, serum, urine or cerebrospinal fluid, for example. Embodiments of the invention relate to an apparatus and method, for example, an immunoassay method, for separating out target molecules in a magnetic field and then analyzing those target molecules with a luminometer.

Magnetic particle washing station

Load lock assemblies for a sample analysis system, such as a mass spectrometry system, include a load lock chamber having longitudinally opposing first and second end portions and a through channel, a door coupled to the second end portion, and a seal assembly coupled to the first end portion. The seal assembly includes a rigid seal housing member coupled to a housing of the load lock chamber. The rigid seal housing member includes a port forming part of the first end portion of the through channel of the load lock chamber. The rigid seal housing member can include a self-centering cartridge and/or a flexure member coupled to the housing of the load lock chamber. Where used, the flexure member has an outer perimeter that extends above and below the rigid seal housing member and includes an aperture that is aligned with the port of the rigid seal housing member.

Load lock chamber assemblies for sample analysis systems and related mass spectrometer systems and methods

Aspects of the present disclosure include sample preparation cartridges including a frame that includes a plurality of wells integrated therewith, where the plurality of wells have a closed bottom and an open top. The frame further includes an opening within the frame having a reaction vessel (RV) or RV cap removably disposed therein, where the plurality of wells and the opening are linearly arranged relative to each other. Also provided are sample preparation cartridges that include a frame, two or more cartridge separation projections on a top side of the frame, and two or more cartridge separation projections on a bottom side of the frame. The cartridge separation projections separate the cartridge and a different cartridge when the cartridge and different cartridge are stacked. Methods of using the sample preparation cartridges, as well as nucleic acid sample preparation units that include the sample preparation cartridges, are also provided.

Sample preparation cartridges and methods for using same

Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples

A container for collecting a biological specimen is provided that includes a peripheral wall extending from a base. The container further includes a longitudinal tower disposed within the container. The tower forms a partition within the container to form at least a first chamber and a second chamber therein, wherein the first and second chambers are in fluid communication with one another. In addition, the container includes an insert disposed within the container opposite the base, the insert comprising at least a first opening and a second opening. The second opening provides access to the second chamber and is further configured to engage a specimen collecting device to leave a portion of the specimen collecting device within the second chamber. The first opening provides access to the first chamber and is further configured to receive a syringe therein for accessing the biological specimen. Associated systems and methods are also provided.

Container and cap for a biological specimen

Growing community of inventors

Westford, MA, United States of America

Mark A Talmer