Riker Laboratories Inc.

Mark A Rustad

Walton J Hammar

Robert A Scherrer

Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Pharmacological methods for using such compounds and synthetic intermediates for preparing such compounds are also disclosed.

Substituted di-t-butylphenols

Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by an alkoxy or benzyloxy group or a benzylthio group, which alkoxy or benzyloxy group is directly substituted by a tetrazole ring, and which benzylthio group is directly substituted by carboxy or tetrazolyl are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Synthetic intermediates for preparing such compounds are also described.

Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a

Substituted di-t-butylphenols and anti-allergic use thereof

Novel compounds which are di-t-butylphenyl alkyl or benzyl ethers which alkyl or benzyl group is substituted by an acidic group are useful an antiallergic agents. Synthetic intermediates for making such compounds are also disclosed.

Di-t-butylphenyl alkyl and benzyl ether nitriles

Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a group which includes carboxyl, tetrazolyl or N-methyltetrazolyl are useful as inhibitors of leukotriene synthesis and as antiallergic agents. Pharmaceutical compositions containing such compounds and pharmacological methods for use of such compounds are also disclosed.

Compounds wherein 2-nitrobenzofuran is substituted by one or two phenyl groups and certain other substituents which are active as antimicrobial agents, processes for their use and intermediates therefor.

Derivatives of 2-nitrobenzofuran

Compounds wherein 2-nitrobenzofuran is substituted by one or two phenyl groups and certain other substituents which are active as antimicrobial agents, a processes for their use and intermediates therefor.

Certain mono-bromo bis-phenyl benzofurans

Certain benzofuran benzene acetic acid type compounds

Diphenylbenzofuran compounds

Compounds wherein a phenylalkanoic acid is substituted by a 2-nitro-3-phenylbenzofuran group which are active as antimicrobial agents, processes for their use and intermediates therefor are described.

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Saint Paul, MN, United States of America

Mark A Rustad