Other

The United States of America As Represented by the Department of Energy

Signature Bioscience, Inc.

Mark A Rhodes

John J Hefti

Barrett Bartell

Scott N Fochs

Robert G Chapman

Kurt Joseph Kramer

Tyler A Palmer

Min Zhao

A coplanar waveguide biosensor and methods of use include a coplanar waveguide transmission line and a sample containment structure. The coplanar waveguide transmission line is operable to support the propagation of an electromagnetic signal and includes a signal line and one or more spaced apart ground elements. The signal line is configured to conduct a time-varying voltage, and the one or more ground elements are configured to maintain a time-invariant voltage, a detection region being formed between a portion of the signal line and a portion of at least one of the one or more ground elements. Detection methods are improved through the enhancement of the electric field in the detection region via impedance discontinuities in the signal line and ground elements. The sample containment structure intersects the detection region of the coplanar waveguide transmission line and includes a cavity configured to hold 1 ml or less of sample solution within the detection region.

Coplanar waveguide biosensor for detecting molecular or cellular events

The present invention provides a method for detecting a molecular event, comprising (1) applying an electromagnetic test signal to a sample in which a molecular event is being detected, whereby the sample interacts with and modulates the test signal to produce a modulated test signal, and (2) detecting the modulated test signal, wherein the applying and detecting take place in a temperature-controlled environment, wherein the temperature-controlled environment comprises the sample, a radiating portion of a signal generating circuit, and a receiving portion of a signal detection circuit and wherein the applying and detecting take place in the environment at a temperature controlled to within &plusmn;0.5&deg; C.

Method and apparatus for detection of molecular events using temperature control of detection environment

An apparatus and method to contain plasma at optimal fill capacity of a metallic container is disclosed. The invention includes the utilization of anodized layers forming the internal surfaces of the container volume. Bias resistors are calibrated to provide constant current at variable voltage conditions. By choosing the appropriate values of the bias resistors, the voltages of the metallic container relative to the voltage of an anode are adjusted to achieve optimal plasma fill while minimizing the chance of reaching the breakdown voltage of the anodized layer.

Apparatus and method for electrical insulation in plasma discharge systems

A portable water survival kit includes a small life raft apparatus which may be attached to and carried by a user. When needed, the small life raft may be quickly removed from a carrying case and inflated through the use of a permanently attached compressed gas cartridge.

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Redwood City, CA, United States of America

Mark A Rhodes