Otonexus Medical Technologies, Inc.

Spentech, Inc.

Other

Waters Instruments, Inc.

Uab Vittamed

Applied Physiology and Medicine

Mark A Moehring

George A Gates

Jay A Chesavage

Daniel Kreindler

Rahul Singh

Charlie Corredor

Caitlin E Cameron

Merrill P Spencer

Arne H Voie

Chad Jason MacDonald

Dar Bahatt

Mark A Curry

John R Klepper

Timothy Myers

Eugene A Saxon

Arminas Ragauskas

Gediminas Daubaris

Thomas A Burton

Vytautas Petkus

Renaldas Raisutis

Dong Ho Choi

Weigang Wang

Henry James Baron, Jr

Rolandas Zakelis

Donald L Davis

Robert Giansiracusa

Anthony J Alleman

Steve Swedenburg

Mailee J Hess

Marc Fine

Asanka S Dewaraja

Thomas O Mera

Joseph H Farnsworth

Ajay Philip Zachariah

Romanas Chomskis

George F Sedivy

Richard F Ferraro

Chad Jason Macdonald

Daubaris Gediminas

Provided herein are systems, devices, and methods to measure auditory signals from a subject to determine a state of a subject. The auditory signals measured may provide a tool to monitor the development of disease state(s) or abnormal physiologic conditions (e.g., wheezing, fluid accumulation, abnormal heart murmur or rhythm, etc).

Wearable auscultation device

Display screen portion having a graphical user interface with an animated icon of a tympanic membrane mobility scale

An ultrasound signal processor uses an excitation generator to cause displacement of a membrane or surface while a series of ultrasound pulses are applied to the membrane or surface. Phase differences between a transmitted signal and received signal are examined to determine the movement of the membrane or surface in response to the applied excitation. An examination of the phase response of the membrane or surface provides a determination as to whether the fluid type behind the membrane or surface is one of: no fluid, serum fluid, or purulent fluid.

Apparatus and method for characterization of a ductile membrane, surface and sub-surface properties

An ultrasound signal processor uses an excitation generator to cause displacement of a tympanic membrane while a series of ultrasound pulses are applied to the tympanic membrane. Phase differences between a transmitted signal and received signal are examined to determine the movement of the tympanic membrane in response to the applied excitation. An examination of the phase response of the tympanic membrane provides a determination as to whether the fluid type behind the tympanic membrane is one of: no fluid, serum fluid, or purulent fluid.

Apparatus and method for characterization of acute otitis media

A device for measuring reflected ultrasound and optical signals may include: an optical source; an optical assembly comprising at least one lens, configured to focus reflected optical illumination from a target onto a detector; and an ultrasound transducer aligned to transmit and receive ultrasound radiation co-axially with the reflected optical illumination and wherein the ultrasound transducer at least partially obstructs a path of the reflected optical illumination. An obstruction may be distant from a focal spot of the optical assembly. The device for measuring reflected ultrasound and optical signals may be particularly useful for characterizing fluid behind an ear drum to diagnose otitis media.

Methods and devices for membrane characterization with ultrasound and optical illumination

An ultrasound transducer may include: a plurality of capacitive ultrasound transducer elements; and a base having a largest dimension sized and shaped to be disposed with an external ear canal, wherein the plurality of capacitive ultrasound transducers is mounted on the base. Each capacitive ultrasound transducer element and the ultrasound transducer are specifically constructed to achieve select desired performance characteristics. The ultrasound transducer may have an angular beam spread through a gaseous medium of greater than 15 degrees and an attenuation loss through the gaseous medium of greater than 10 dB measured at a distance 12.5 mm to 25 mm along a primary transmission axis of the ultrasound transducer. The ultrasound transducer may be particularly useful for characterizing fluid behind an ear drum to diagnose otitis media.

Small scale, capacitive ultrasound transducer devices with improved directionality and methods for their use

Disclosed herein are systems and methods for classifying a tympanic membrane by using a classifier. The classifier is a machine learning algorithm. A method for classifying a tympanic membrane includes steps of: receiving, from an interrogation system, one or more datasets relating to the tympanic membrane; determining a set of parameters from the one or more datasets, wherein at least one parameter of the set of parameters is related to a dynamic property or a static position of the tympanic membrane; and outputting a classification of the tympanic membrane based on a classifier model derived from the set of parameters. The classification comprises one or more of a state, a condition, or a mobility metric of the tympanic membrane.

Machine learning for otitis media diagnosis

Small-scale capacitive ultrasound transducer devices and methods

Disclosed herein is a device for modeling properties of an ear. The device includes an artificial tympanic membrane and a housing coupled to the artificial tympanic membrane. The housing defines an interior portion coupled to an interior surface of the artificial tympanic membrane. The interior portion has an adjustable volume or an adjustable type of fluid and an adjustable gas pressure. Adjustment of the volume or type of fluid and the gas pressure changes a membrane movement to produce selected movement properties according to a mobility scale.

Systems and methods for simulating a tympanic membrane

Apparatus and method for characterization of a ductile membrane, surface, and sub-surface properties

An OCT apparatus and method for characterization of a fluid adjacent to a tympanic membrane has a low coherence source which is coupled to a splitter which has a measurement path and a reference path. The reference path is temporally modulated for length, and the combined signals from the reference path and the measurement path are applied to a detector. The detector examines the width of the response and the time variation when an optional excitation source is applied to the tympanic membrane, the width of the response and the time variation forming a metric indicating the viscosity of a fluid adjacent to the tympanic membrane being measured.

Optical coherence tomography device for otitis media

An acoustic otoscope generates volume change excitations of either a trapezoidal or sinusoidal waveforms which are coupled into a sealed ear canal using a speculum tip. The change in volume results in a pressure change, for which a pressure measurement is taken during the volume change excitation interval. In one example, a trapezoidal time-domain volume change is presented, and a pressure measurement waveform is stored, the pressure measurement waveform thereafter examined to find a change of slope point in time, after which the pressure measurement waveform is scaled to be equal to the volume change waveform at that same point in time, a difference between scaled pressure measurement and volume excitation is formed, and examined for peak value prior to the earlier determined change in slope point in time.

Acoustic otoscope

Growing community of inventors

Seattle, WA, United States of America

Mark A Moehring