Fractyl Health, Inc.

Fractyl Laboratories, Inc.

Mark A Manasas

Harith Rajagopalan

Jay D Caplan

Andrew Owen Coats

J Christopher Flaherty

Philip Stephen Levin

Christopher James Kadamus

R Maxwell Flaherty

Craig Morris Gardner

Phillip S Levin

Andrew Hollett

Charles Abele

Thomas Kochem

Sara Morneau

Jeffrey Johnson

Christopher J Kadamus

Andrew Coats

Jay Caplan

Phillip Levin

Michael Biasella

An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

Injectate delivery devices, systems and methods

A device for ablating target tissue of a patient with an ablative fluid is provided. An elongate shaft includes a proximal portion and a distal portion, and at least one fluid delivery element is attached to the distal portion. The device can be configured to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

Ablation systems, devices and methods for the treatment of tissue

A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided.

Heat ablation systems, devices and methods for the treatment of tissue

A device for expanding tissue comprises at least one fluid delivery tube and at least one fluid delivery element in fluid communication with the at least one fluid delivery tube. The at least one fluid delivery tube comprises a proximal end, a distal end, and a lumen therebetween. The device is constructed and arranged to perform a near full circumferential expansion of luminal wall tissue. Systems and methods are also provided, including a system for expanding tissue layers and treating tissue proximate to the expanded tissue layers.

Tissue expansion devices, systems and methods

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Lexington, MA, United States of America

Mark A Manasas