University of Rochester

Mark A Lifson

Benjamin L Miller

Jared A Carter

Dhruba Jyoti Basu Roy

Disclosed is a sensor chip for detecting a target molecule in a sample. The sensor chip includes a substrate having a surface and a layer of hydrogel particles immobilized on the substrate surface at two or more locations on the surface, wherein the hydrogel particles at a first location comprise a plurality of first probe molecules bound to the particles and the hydrogel particles at a second location comprise a plurality of second probe molecules bound to the particles. Systems that include the sensor chip, as well as methods of preparing and using the sensor chip, are also disclosed.

Polymer microparticle-based method for probe deposition in label-free biosensors

Disclosed is a method of preparing a biosensor that involves providing a substrate including a surface having a topographical pattern formed at one or more sites on or in the surface, coating the substrate with a solution including hydrogel particles, wherein the hydrogel particles self-assemble on the surface to mask the surface except at the one or more sites, and binding one or more capture molecules to the one or more sites to form the biosensor. Systems that include the biosensor, as well as methods of using the biosensor, are also disclosed.

Growing community of inventors

Rochester, NY, United States of America

Mark A Lifson