Smithkline Beecham Corporation

Smithkline Beckman Corporation

Other

Pfizer Corporation

Mark A Levy

Dennis Alan Holt

Brian W Metcalf

Conrad John Kowalski

Michael Thomas Clark

Thomas O Lindsey

Richard D Hedde

Hector Wasunna Alila

Hye-Ja Oh

Ann Marie Tickner

Jack R Tester

17 substituted acyl-3-carboxy 3,5-diene steroidals as .alpha.-reductase

Invented are 17.alpha. and 17.beta.-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates and processes used in preparing these compounds.

17-.alpha. and 17-.beta. substituted acyl-3-carboxy-3, 5-dienes and use

17-.alpha.and 17-.beta.substituted acyl-3-carboxy-3,5-dienes and use in

17.alpha. and 17.beta.-substituted estra-1,3,5(10)-triene-3-carbboxlic

Reduction of boar odor in meat

Invented are 17.beta.-substituted acyl-4-aza analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates and processes used in preparing these compounds.

17.alpha. and 17.beta. substituted acyl 4 aza steroids

Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.

Steroid 5-alpha-reductase inhibitors

Invented are 3-acetic acid-steroidal compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase including using these compounds to reduce prostate size and to treat prostatic adenocarcinoma. Also invented are intermediates used in preparing these compounds.

Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors

Intermediates in the preparation of steriod 5-alpha-reductase inhibitors

Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase.

11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod

Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are methods for preparing these compounds.

7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha

The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase.

Phosphinic acid substituted steroids as inhibitors of steroid

Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.

Steriod 5-alpha-reductase inhibitors

Invented are 3-nitro- substituted steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.

3-substituted nitro-steroid derivatives as 5-.alpha.-reductase inhibitors

Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.

Growing community of inventors

Wayne, PA, United States of America

Mark A Levy