University of California

The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States of America

The Government of the United States of America

The United States of America As Represented by Nih

Charles S. Zuker

Jayaram Chandrashekar

Gregory A. Nelson

Mark A. Hoon

Yifeng Zhang

Nicholas J. P. Ryba

Mark A Hoon

Charles S Zuker

Jon Elliot Adler

Ken Mueller

Nick Ryba

Nicholas J P Ryba

Gregory A Nelson

Greg Nelson

Santosh K Mishra

James Inglese

Patricia Dranchak

Hans Juergen Solinski

Nicholas Jp Ryba

Nicholas JP Ryba

Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.

Compositions and methods for the inhibition of pruritus

Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.

Methods of treating or preventing pruritis by blocking natriuretic polypeptide b

Methods of treating or preventing pruritis by blocking natriuretic polypeptide B

The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.

Method for identifying compounds that modulate a T2R taste receptor

The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1

Nucleic acids encoding T2R bitter taste receptors

The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.

Methods for identifying compounds which modulate T2R bitter taste receptors

Nucleic acid encoding a T2R taste receptor

The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.

Mammalian sweet taste receptors

Methods for identifying modulators of SF taste receptor signaling

Nucleic acids encoding T2R taste receptors

Growing community of inventors

Kensington, MD, United States of America

Mark A Hoon