Albany Molecular Research, Inc.

Bone Care International, Inc.

Mark A Helle

Harold Meckler

Steven James Collier

Bernhard J Paul

William Bert Geiss

Brian Thomas Gregg

David C Burdick

Betina Biolatto

Alicia J Habershaw

Frédéric Jos

The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R, R, and Rare the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R, R, and Rdefined herein.

Process for production of delta-9-tetrahydrocannabinol

The invention provides a method for making 24(S)-hydroxyvitamin D which is a stereospecific synthesis.

Method for making 24(S)-hydroxyvitamin D2

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Westerlo, NY, United States of America

Mark A Helle