Amgen Inc.

Unl Holdings LLC

Tandem Diabetes Care, Inc.

Unitract Syringe Pty Ltd

Surgical Laser Technologies, Inc.

Neoforce Group, Inc.

Thomas Jefferson University

Mark A Destefano

Ian B Hanson

Paul F Bente, Iv

Lawton Laurence

John Christian Love

Sean M O'connor

Sheldon B Moberg

Scott Robert Gibson

Margaux Frances Boyaval

Kevin Lee Bokelman

Daniel Shawn Codd

Rajan Ramaswamy

Matthew J Clemente

Scott Beaver

Gautam N Shetty

Basel Hasan Taha

Robert Decker

Ian P Dardani

Daniel Davenport

Ryan Michael Agard

Nicholas J Ciccarelli

Mark C Estes

Jeffrey I Joseph

Iv Bente Paul F

Antonio Ubach

Danielle Feldman

John C Love

Kenneth C Hsu

Shaun Robert Devitt

David S Gillett

Amrith Karunaratne

Otho Newman Boone

Amber Stansberry

Paul Bente

Paul Strasma

Justin Coker

Monica Ferrante

Stewart I Jaffe

Paul J Strasma

Brian M Shelton

Paul F Bente

Alexis Marie Dechelette

Robert G Jeter

Scott R Gibson

Kevin L Bokelman

Daniel S Codd

Iv Paul F Bente

Paul F Bente Iv

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Drug delivery device, method of manufacture, and method of use

A drive mechanism () for use with a drug container () in a drug pump, the drug container () having a barrel () and a plunger seal (), including a tether, an electrical actuator () and a gear interface. Rotation of the gear interface is controlled by the actuator (). A gear assembly rotationally engages with the gear interface. The gear assembly includes a main gear and a regulating mechanism. Release of the tether is metered by the gear assembly through the regulating mechanism. A piston () is connected to the tether and is disposed in the barrel () and configured to translate axially within the container. A biasing member is disposed at least partially within the barrel () and is retained in an energized state between the piston () and drive housing, wherein the release of the tether controls the free expansion of the biasing member from its energized state and the axial translation of the piston ().

Drug delivery device and method

A system for delivering fluid to a user transcutaneously includes a torsion spring, a drive wheel, a linear slide having a stylet attached thereto, and a cannula. The torsion spring, when actuated, is configured to rotate the drive wheel to cause the linear slide to move axially to drive the stylet and cannula into a user-s skin.

Linear insertion device with rotational drive

An insertion mechanism for a drug pump includes an insertion mechanism housing; a sleeve; a rotational biasing member initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the sleeve. The needle is inserted into a target tissue by the rotational biasing member and interaction between the hub and housing. Retraction of the needle is caused by decompressing or de-energizing of the retraction biasing member. A drug delivery pump includes an activation mechanism, a drive mechanism, a sterile access connection, and the insertion mechanism. Assembly and operation methods are provided.

Rotationally biased insertion mechanism for a drug delivery pump

Drive mechanisms for drug delivery pumps

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device includes a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector defines a sterile fluid flowpath between the container and the insertion mechanism. A cannula initially disposed about the needle is included.

An insertion mechanism for a drug pump includes an insertion mechanism housing; a manifold guide; an insertion biasing members initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the manifold guide; and a manifold having a septum and a cannula, wherein the annular space between the septum and the cannula defines a manifold header. The needle and cannula are inserted into the body of a user by the insertion biasing member(s), after which only the needle is retracted. Retraction of the needle may open a fluid pathway from the manifold header to the body through the cannula. A drug delivery pump includes an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism. Assembly and operation methods are provided.

Insertion mechanism for a drug delivery pump

An insertion mechanism and methods of assembly and operation of a drug pump may include an insertion mechanism housing; a housing cap; a manifold guide; an insertion biasing member initially held in an energized state; a retraction biasing member connected to a hub connected to a proximal end of a needle; and, optionally, a clip retainer. The retraction biasing member is held initially in an energized state between the hub and manifold guide. A manifold has a manifold body and one or more septa defining a manifold header. The retraction biasing member may be held initially energized between the hub and the clip retainer. The needle is advanced by the insertion biasing member(s) from the initial configuration to an administration configuration, opening a fluid pathway from the manifold header to the target. The pump may include an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism.

Rigid needle insertion mechanism for a drug delivery pump

A controlled delivery drive mechanism includes a drive housing, a piston, and a biasing member initially retained in an energized state and is configured to bear upon an interface surface of the piston. The piston is configured to translate a plunger seal and a barrel. A tether is connected between the piston and the winch drum to restrain the free expansion of the biasing member and the free axial translation of the piston upon which the biasing member bears upon. The drive mechanism may further include a gear assembly and an escapement regulating mechanism configured to control the rotation of the gear assembly to release the tether from the winch drum. The metering of the tether by the escapement regulating mechanism controls the rate or profile of drug delivery to a user.

Controlled delivery drive mechanisms for drug delivery pumps

An insertion mechanism () for a drug pump () includes an insertion mechanism () housing (); a sleeve (); a rotational biasing member () initially held in an energized state; a retraction biasing member () and a hub () connected to a proximal end of a needle (), wherein the retraction biasing member () is held initially in an energized state between the hub () and the sleeve (). The needle () is inserted into a target tissue by the rotational biasing member () and interaction between the hub () and housing (). Retraction of the needle () is caused by decompressing or de-energizing of the retraction biasing member (). A drug delivery pump includes an activation mechanism (), a drive mechanism (), a sterile access connection (), and the insertion mechanism (). Assembly and operation methods are provided.

Growing community of inventors

Collegeville, PA, United States of America

Mark A Destefano