Kosan Biosciences Incorporated

University of California

Pfizer Corporation

University of Pennsylvania

Advanced Genetic Systems, Inc.

Mark A Burlingame

Gary W Ashley

Christopher Carreras

Simon James Shaw

Daniel V Santi

David C Myles

Isaac C Chan-Kai

Amos B Smith, Iii

Yandong Li

Adam Renslo

Yaoquan Liu

Hong Fu

Alan Frankel

Yue Chen

Kurt Frederick Sundermann

Yong Li

Robert Nakamura

Brian Scott Freeze

Tomoyasu Hirose

Ignació Brouard Martin

Hao Zheng

Provided herein, inter alia, are methods and compounds for treating an HIV infection.

Compounds and methods for treating HIV infection

15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.

7-quinolyl ketolide antibacterial agents

Compounds having a structure according to formula (I) where R, R, R, R, R, and Rare as defined herein, are useful as prokinetic agents.

Motilide compounds

Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof

Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.

Polyketides and antibiotics

Racemic thioesters for production of polyketides

Growing community of inventors

San Francisco, CA, United States of America

Mark A Burlingame