Merck + Co., Inc.

Marjorie See Waters

David Askin

Peter Emmanuel Maligres

J Christopher McWilliams

Jennifer A Cowen

Feng Xu

Guy R Humphrey

Chunhua Yang

Wei Xu

J Michael Williams

Cameron Cowden

Kimberly A Petrillo

Matthew M Bio

A process is provided for the preparation of branched-chain ribonucleosides of formula (I): from the 1,2-anhydroderivatives of formula (II). wherein PG is a hydroxyl protecting group, B is a purine or pyrimidine nucleobase, and Ris Calkyl. The compounds of formula (I) are inhibitors of HCV polymerase useful in the treatment of HCV infection.

Process for preparing branched ribonucleosides from 1,2-anhydroribofuranose intermediates

Amine salts of -( -methyl-pyrimidin- -yl)- -( -tetrahydro-&lsqb; &rsqb;-naphthyridin- -yl)-nonanoic acid are potent antagonists of the integrin &agr;v&bgr; receptor and are useful for the prevention and/or treatment of osteoporosis and vascular restenosis, as well as conditions associated with excessive angiogenesis, such as macular degeneration, diabetic retinopathy, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth. The invention also relates to a process for the preparation of the novel salts as well as pharmaceutical compositions containing the salts and methods of using the salts. Also disclosed are (R)- and (S)-( -methylpyrimidin- -yl)- -( -tetrahydro-&lsqb; &rsqb;naphthyridin- -yl)-nonanoic acid in the form of a zwitterion trihydrate.

Amine salts of an integrin receptor antagonist

The present invention is directed to a process for synthesizing 1,5 disubstituted imidazoles with biaryl components of the formula (I):

Process for synthesizing biaryl inhibitors of farnesyl-protein transferase

The present invention is directed to a process for synthesizing 1,5-disubstituted imidazoles, which are useful in the preparation of farnesyl-protein transferase inhibitors.

Process for making 1,5-disubstituted imidazoles

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Cranbury, NJ, United States of America

Marjorie See Waters