The United States of America, As Represented by the Secretary, Department of Health and Human Services

Istituto Superiore Di Sanita

Other

The United States of America As Represented by the Secretary of

The United States of America As Represented by the Department of Health

Marjorie Robert-Guroff

Barbara Ensoli

Bo Peng

Rebecca Voltan

Robert C Gallo

Samuel Broder

Frank A Robey

Shuzo Matsushita

Tracy A Harris-Kelson

This invention provides improved replication-competent adenoviral vectors. The improved vectors have both a hybrid regulatory unit that provides for high level transgene expression. The vectors can be use, e.g., for therapeutic or prophylactic purposes.

Replication-competent adenoviral vectors

The present invention relates to synthetic peptide analogues useful as therapeutic agents, immunogens or for the diagnosis of disease. In particular, it relates to peptide multimers which maintain the conformation of the native proteins from which they are derived. Peptomers constructed from peptides derived from gp120 of the human immunodeficiency virus are exemplified.

Peptomers with enhanced immunogenicity

This invention relates to a method to measure natural human antibodies in sera which will neutralize HTLV-III infection in an in vitro assay. Basically, cell-free virus is incubated with serum and used to infect H9 cells, which are then put in culture for three days, and viral infectivity is assayed using a monoclonal antibody specific for HTLV-III p24 in an immune fluorescent assay.

Method for detecting HTLV-III neutralizing antibodies in sera

The present invention is an immortalized B-cell line which produces a human monoclonal antibody IgG-Kk which specifically binds to the envelope antigen of human T-cell leukemia virus Type 1 (HTLV-I). This monoclonal antibody is useful as a diagnostic reagent by binding to the antigen specifically expressed on the surface of HTLV producing cells. Furthermore, this monoclonal antibody is useful as a therapeutic reagent, in combination with complement, for the lysis of HTLV-1 producing cells.

Cell line producing human monoclonal antibody which binds to HTLV-I

Growing community of inventors

Rockville, MD, United States of America

Marjorie Robert-Guroff