Salvia Bioelectronics B.v.

Marjolein Schets

Hubert Martens

Daniel Schobben

Wim Pollet

In general, implantation of neurostimulation systems or device includes subcutaneous or percutaneous placement of at least the electrodes. Preferred are minimally invasive implantation procedures, systems and devices that can reliably operate for extended periods, and systems and devices providing a high degree of comfort for the subject. The implantation specialist may need to address adequate placement of the electrodes with respect to the nerve tissue to be stimulated, and to choose between one or more convenient locations for the elements of the system or device. Methods are provided comprising forming a firstand secondincision on opposite sides of a target location, and introducing a first introducer sheathunder the skin with a maximum internal transverse cross-section less than the further maximum transverse cross-sectionof an implantable stimulator. Such a method is advantageous if the maximum transverse cross-sectionof the further portion is at least 1.2 times greater than the maximum transverse cross-sectionof the first portion&#x2014;the dimensions of the implantation tools may be reduced. A further method is provided wherein the first portionwith at least two electrodesis introduced in the skin layers between the nerve tissueto be stimulated and above or in the aponeurosis layer By being implanted deeper and/or more accurately, comfort and/or reliability for the subject may be improved. In addition, the chance that the stimulator is implanted under the nerve tissue is greatly increased.

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Eindhoven, Netherlands

Marjolein Schets