American Cyanamid Company

Marja Van Zeijl

Bryan M O'Hara

Stephen V Johann

The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding for Gibbon Ape Leukemia Virus (GALV). Differences for the type of retroviruses interacting with the receptors exist. The protein encoding by the GLVR2 gene, cells transformed or transfected by the gene and vectors containing the gene are also disclosed.

Amphotropic virus receptor

The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding Gibbon Ape Leukemia Virus (GALV) receptor. Differences in the type of retroviruses interacting with the receptors exist. The protein encoded by the GLVR2, cells transformed or transfected by the gene, and vectors containing the gene are also disclosed.

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Cornwall, NY, United States of America

Marja Van Zeijl