Caliper Technologies Corporation

Caliper Life Sciences, Inc.

Marja Liisa Alajoki

Robert S Dubrow

H Garrett Wada

J Wallace Parce

Anne R Kopf-Sill

Andrea W Chow

Benjamin N Wang

Javier Anibal Farinas

Yevgeny Yurkovetsky

Apparatus and methods for modulating flow rates in microfluidic devices are provided. The methods involve modulating downstream pressure in the device to change the flow rate of materials in an upstream region of the device. Such methods include electrokinetic injection or withdrawal of materials through a side channel and the use of an absorbent material to induce wicking in the channel system. The apparatus provided includes a prefabricated wick in the device to provide for flow rate control. Additional methods for determining velocity of a particle and cell incubation time are also provided.

Apparatus for continuous liquid flow in microscale channels using wicking

Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.

Focusing of microparticles in microfluidic systems

Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.

Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection

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Palo Alto, CA, United States of America

Marja Liisa Alajoki