Warszawski Uniwersytet Medyczny

Instytut Farmaceutyczny

Molecure S.a.

Mariusz Marek Gruza

Marzena Mazur

Wojciech J Czestkowski

Agnieszka Bartoszewicz

Oliwia Zegrocka-Stendel

Grzegorz Grynkiewicz

Marta Laszcz

Kamil Jatczak

Katarzyna Koziak

Malgorzata Dutkiewicz

Piotr Niedziejko

Piotr Cmoch

Iwona Grabowska

Dorota Maciejko

Magdalena Kowalewska

Tomasz Giller

Krzysztof Bojakowski

Katarzyna Filip

Gleb Andryianau

Adam Golebiowski

Piotr Pomaranski

Katarzyna Drzewicka

Lukasz Krzeminski

Diana Papiernik

Katarzyna Piwowar

Damian Kusmirek

Kamil Lisiecki

Michal Kowalski

Przemyslaw Wanat

Described herein is compound including a protoescigenin derivative having pharmacological properties. Also described are a process of its preparation, and the use of such a compound as a medicament, especially for treating vascular disorders. A pharmaceutical composition comprising such compound is further described.

Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound

A process for the preparation of protoescigenin by hydrolysis of escin isolated from. The process includes the following steps: a two-step hydrolysis first under acidic and then basic conditions, enrichment of the crude mixture of sapogenins with protoescigenin, an isolation of the mixture of sapogenins in a solid form, and a purification of the obtained solid and isolation of high purity protoescigenin. The invention also relates to protoescigenin monohydrate in a crystalline form and the preparation thereof. Protoescigenin is a polyhydroxy aglycone, which can be used as a synthon in the chemical modifications of naturally occurring saponins.

Process for the preparation of protoescigenin

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Warsaw, Poland

Mariusz Marek Gruza