Koninklijke Philips Corporation N.v.

Philips Lighting Holding B.v.

Marius Iosif Boamfa

Rieko Verhagen

Reinhold Wimberger-Friedl

Bastiaan Wilhelmus Maria Moeskops

Erik Martinus Hubertus Petrus Van Dijk

Kiran Kumar Thumma

Mark Thomas Johnson

Derk Jan Wilfred Klunder

Anke Pierik

Frank Anton Van Abeelen

Susanne Maaike Valster

Maarten Marinus Johannes Wilhelmus Van Herpen

Peter Dirksen

Menno Willem Jose Prins

Jonathan Alambra Palero

Babu Varghese

Marcus Antonius Verschuuren

Pieter Jan Van Der Zaag

Sjoerd Stallinga

Albert Hendrik Jan Immink

Marinus Bastiaan Van Leeuwen

Elvira Johanna Maria Paulussen

Theodoor Bastiaan Johannes Haddeman

Arnoldus Johannes Martinus Jozeph Ras

Marc Alexander Pastoors

Thea Van Der Wijk

Michel Jozef Agnes Asselman

Thomas Petrus Hendricus Warmerdam

Richard Joseph Marinus Schroeders

Menno W J Prins

Marius Gabriel Ivan

Reinder Niels Lap

Remco Den Dulk

Derk J W Klunder

Nikolaj Vasiljevitsj Zjiroecha

Joost Hubert Maas

Dirkjan Bernhard Van Dam

Maatje Koets

Maarten M J W Van Herpen

Roland Cornelis Martinus Vulders

Albert H J Immink

Prarthana Shrestha

Franciscus Antonius Kneepkens

Erik M H P Van Dijk

Marinus Bastiaan (Rien) Van Leeuwen

Dirk Leo Joep Vossen

Michel J M Bruyninckx

Dirk L J Vossen

Eric Gerard Marie Van Kempen

Rowan Cornelis Van Hoogenhuizen

Eldert Zeinstra

Giorgos Mazarakis

Nuno Filipe Baltazar Dos Santos

Richard J M Schroeders

A shaving unit () for use in an electric shaver () comprises at least one hair-cuffing unit () comprising an external cutting member () having hair-entry openings () in a cutting track surface () and an internal cutting member having at least one hair-cutting element and being movable relative to the external cutting member (), and a base member () supporting the at least one hair-cutting unit (). The shaving unit () further comprises at least one skin-heating unit () comprising a skin-contacting member () having a skin-contacting surface () arranged adjacent to the at least one hair-cutting unit () to contact the skin during use of the shaving unit (), and at least one infrared or near-infrared light source () integrated in the skin-contacting member (), thermally coupled to the skin-contacting surface () and arranged to emit infrared or near-infrared light via the skin-contacting surface ().

Shaving unit and electric shaver comprising a main body and a shaving unit

According to an aspect, there is provided a treatment device for performing a treatment operation on or to a subject. The treatment device comprises: an optical diffuser arranged on the treatment device such that an outer surface of the optical diffuser is proximate to, or in contact with, skin of the subject when the treatment device is to be used to perform the treatment operation; and an imaging unit for obtaining one or more images using light passing through the optical diffuser into the treatment device; wherein the treatment device is further configured for providing one or more images to a processing unit for determination of whether the treatment device is in contact with the skin.

Treatment device and method

The present invention relates to image analysis of pathology images. In order to improve reliability in image analysis of pathology images, a method is provided for providing support in identifying at least one feature of a tissue sample in a microscopic image. The method comprises the steps of providing a first image of a first microscopy 5 modality representing an area of the tissue sample, providing a second image of a second microscopy modality representing the said area of the tissue sample, generating a first high intensity image by applying a first high intensity filter to the first image or a first low intensity image by applying a first low intensity filter to the first image to obtain first information of the at least one feature, generating a second high intensity image by applying 10 a second high intensity filter to the second image or a second low intensity image by applying a second low intensity filter to the second image to obtain second information of the at least one feature, calculating a correlation of an image pair comprising one of the first high intensity image and the first low intensity image and one of the second high intensity image and the second low intensity image for correlating the first information and the second 15 information of the at least one feature, and outputting the calculated correlation for providing support in identifying the at least one feature of the tissue sample.

Correlated image analysis for 3D biopsy

There is provided an apparatus comprising: a base substrate and a component substrate having at least two electronic components arranged thereon. At least one aperture is formed through an entire thickness of the component substrate. The at least one aperture is formed in an interspace between the at least two electronic components. The component substrate is coupled to the base substrate using a solder joint. Each of the at least two electronic components may comprise a light emitting diode element. A method of manufacturing an apparatus is also disclosed.

Apparatus and a method of manufacturing an apparatus

The present invention relates to fluorescence imaging. In order to enhance compatibility with multiple fluorescence channels for calibrating a fluorescence microscope, a calibration slide is provided that comprises a substrate and a pixel layout. The pixel layout comprises a plurality of spaced apart metal nanostructures arranged on a surface of the substrate. The metal nanostructures are arranged to produce plasmon resonances that allow absorbing light at an excitation wavelength to produce photo-luminescence and/or fluorescence light for generating a fluorescent image. The fluorescent image comprises a plurality of pixel intensity values that are provided for calibration of a fluorescence microscope.

Fluorescence calibration slide

There is provided a hair cutting device for cutting hair on a body of a subject, the hair cutting device comprising a light source for generating light at one or more specific wavelengths corresponding to wavelengths absorbed by one or more chromophores in or on hair; a cutting element that comprises an optical waveguide that is coupled at a first end to the light source to receive light, wherein a portion of a sidewall of the optical waveguide forms a cutting face for contacting hair; a light sensor that is coupled to the optical waveguide away from the first end, wherein the light sensor is for measuring the light level in the optical waveguide and for providing an output signal representing the measured light level; and a control unit that is coupled to the light source, and coupled to the light sensor to receive the output signal, wherein the control unit is configured to determine a measure of the amount of input light transmitted across the optical waveguide from the measured light level and an input light level at the first end of the optical waveguide; and to control the power of the light generated by the light source based on the determined measure.

Hair cutting device and a method of operating a hair cutting device

The present invention relates to digital pathology. In order to improve uniformity at microscopic level and to enhance stability in time for color calibration, a calibration slide () is provided for a digital pathology scanning microscope. The calibration slide comprises a substrate () and a pixel layout () comprising a plurality of spaced apart metal nanostructures () arranged on a surface () of the substrate. The substrate is optically transparent. The metal nanostructures are arranged to produce plasmon resonances for generating a color image under a bright-field illumination. The color image comprises a plurality of calibration color values that are provided for calibrating a digital pathology imaging system.

Calibration slide for digital pathology

A hair cutting device for cutting hair on a body of a subject includes a laser light source, and a light guiding element for guiding light from the light source to the cutting element. The cutting element includes an optical waveguide for receiving light from the light guiding element. The light guiding element has a tapered section in which a diameter of the light guiding element reduces from a light source side diameter to a cutting element side diameter. A portion of a sidewall of the optical waveguide of the cutting element forms a cutting face for contacting hair.

Cutting assembly for a hair cutting device

The present invention relates to digital pathology. In order to improve the workflow in the process of selecting a region of interest of an unstained sample to be removed for molecular diagnostic, a method () is provided for selecting a sample removing area of an unstained sample to be removed for molecular diagnostic. The method comprises the following steps: In a first step, also referred to as step a), a reference removing area is selected in a reference image of a reference slice of an object, wherein biological material in the reference slice is stained. In a second step, also referred to as step b), a digital sample image of a sample slice of the object is obtained under an imaging setting. The biological material in the sample slice is unstained. The sample slice is received on a sample slide and positioned in an optical path between a light source and an image detector. In the optical path between the light source and the image detector, it is further provided a contrast enhancing arrangement for improving contrast between the unstained biological material and background. Light is provided passing through the sample slice to be received by the image detector. In a third step, also referred to as step c), the digital sample image is registered with the reference image for translating the reference removing area in the reference image to the digital sample image. In a fourth step, also referred to as step d), a sample removing area is identified in the digital sample image based on the translated reference removing area.

Digital pathology system

The present invention relates to digital pathology, and relates in particular to a digital pathology scanner illumination unit. In order to provide digital pathology scanning with improved illumination, a digital pathology scanner illumination unit () is provided that comprises a light source (), a light mixing chamber (), and a light diffuser (). The light source comprises a plurality of light elements () that are arranged longitudinally along a linear extension direction. The mixing chamber comprises a transparent volume () providing a mixing distance (DM) between the plurality of the light elements and the light diffuser such that light with a uniform intensity is provided at a downstream edge () of the mixing chamber; and the mixing chamber is arranged, in terms of light propagation, between the plurality of the light elements and the light diffuser. Further, the light diffuser comprises a diffusing material such that the light is transformed into light that has uniformity at different angles, in particular low angles.

Illumination unit for digital pathology scanning

The present invention relates to digital pathology. In order provide enhanced use of available imaging radiation, a digital pathology scanner () is provided that comprises a radiation arrangement (), a sample receiving device (), an optics arrangement (), and a sensor unit (). The radiation arrangement comprises a source () that provides electromagnetic radiation () for radiating a sample received by the sample receiving device. Further, the optics arrangement comprises at least one of the group of a lens () and a filter () that are arranged between the sample receiving device and the sensor unit. The sensor unit is configured to provide image data of the radiated sample. Still further, a lens array arrangement () is provided that comprises at least one lens array () arranged between the source and the sample receiving device. The at least one lens array comprises a plurality of linear cylindrical lenses () that modulate the electromagnetic radiation from the source such that, in an object plane, a radiation distribution pattern () is generated with a plurality of first parts of intensified radiation and a plurality of second parts of weak radiation.

Illumination in digital pathology scanning

A fluid disinfection system comprising at least one UV light source to provide UV radiation into a chamber. The chamber containing an amount of fluid to be disinfected and fitted with at least one adjustable wall. The adjustable wall positioned on an upper surface of the fluid to reflect UV radiation within the amount of liquid. This adjustable wall effectively providing a variable volume chamber in which fluid disinfection can occur.

Recipient with variable geometry for UV water purification

The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

Multi-compartment device with magnetic particles

The invention relates to real-time array PCR cartridges. The cartridge () has a fluid chamber () for a fluid bath () and a first support element () for fixing a microarray () in the fluid chamber (). Thereby the first support element () fixes the microarray () in such a way that a change of a size of the microarray () due to thermal expansion of the microarray () is possible without inducing substantial mechanical stress to the cartridge (). Thereby the cartridge materials chosen independently from thermal expansion coefficients of different microarrays that are to be inserted and fixed into the cartridge ().

Cartridge for an amplification process

A detection system, comprising: a radiation source () for providing input radiation; a radiation focusing arrangement () for providing the input radiation to an analysis region of a sample ();&#x2014;a radiation collection () arrangement for collecting output radiation from the analysis region of the sample resulting from interaction of the input radiation with the sample; a radiation detector () for detecting the collected output radiation; operating means () for operating the detection device in a first detection mode and a second detection mode, wherein in the first detection mode the analysis has a first size and/or shape and wherein in the second detection mode the analysis region has a second size and/or shape that is different from the first size and/or shape.

Detection system and method

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Eindhoven, Netherlands

Marius Iosif Boamfa