Norskhydro Asa

Clavis Pharma Asa

University of Alberta

Mount Sinai School of Medicine

Clavis Pharma as

Marit Liland Sandvold

Finn Myhren

Ole Henrik Eriksen

Are Dalen

Bernt B&oslash;rretzen

Steinar Hagen

James F Holland

Carol E Cass

Lewis R Silverman

James D Young

The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents and pharmaceutical formulations containing them.

Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents

This invention provides monoclonal antibodies that recognize hENT1. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and/or prophylactic in disorders associated with aberrant hENT1 expression and/or activity.

Anti-human equilibrative nucleoside transporter 1 (hENT1) antibodies and methods of use thereof

The present invention is directed toward compounds of Formula (I) as follows: wherein, where the crossing dashed line illustrates the bond formed joining Rto the molecule of Formula (I);

Azacytidine analogues and uses thereof

This invention relates to certain unsaturated fatty acid derivatives of therapeutically active 1,3-dioxolane nucleoside analogues and to pharmaceutical formulations containing them. The said derivatives fall within formula (I). Compounds of formula (I) can be used in the treatment of a cancerous disease, including solid tumors and haematological cancers such as leukaemias, lymphomas and multiple myelomas. 

Dioxolane derivates for the treatment of cancer

The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and carboxylic acid ester groups are modified by replacing one or more of these functional groups by a lipophilic group selected from those of the formula: RCOO&mdash;, RCONH&mdash;, RCOS&mdash;, RCH O&mdash;, RCH NH&mdash;, &mdash;COOCH R, &mdash;CONHCH R and &mdash;SCH R, wherein R is a lipophilic moiety selected from cis-8-heptadecenyl, trans-8-heptadecenyl, cis-10-nonadecenyl and trans-10-nonadecenyl.

Fatty acid derivatives

The invention provides Gemcitabine esters or amides in which the 3&prime;- and/or 5&prime;-OH group and/or the N -amino group is derivatised with a C - and/or C -saturated or mono-unsaturated acyl group, preferably an acyl group selected from oleoyl, elaidoyl, cis-eicosenoyl and trans-eicosenoyl. The Gemcitabine esters and amides are useful as anti-cancer and anti-viral agents.

Growing community of inventors

Porsgrunn, Norway

Marit Liland Sandvold