Orthovita, Inc.

Marissa M Conrad

James Philip Murphy

Charanpreet S Bagga

Erik M Erbe

Theodore D Clineff

Matthew B Havener

Zachary S Szczerbinski

Abigail Cohen

Alice Bachert

Lauren S Valdes

Jenny E Morgan

The present invention generally relates to bioactive composites of polymer and glass and, more particularly, to bioactive implants. The present invention also relates to methods of manufacturing bioactive composites. The bioactive composite finds utility in a variety of load-bearing clinical applications including spine, orthopaedic and dental procedures.

Bioactive composites of polymer and glass and method for making same

Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.

Bioactive load-bearing composites

The invention relates to methods for fabricating a flowable hemostatic composition. The invention also relates to hemostatic compositions and methods for promoting wound healing. In various embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the ratio of weight percent collagen solids to weight percent crosslinker when crosslinking the collagen. In other embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the temperature and rate of freezing when drying the composition during fabrication. In some embodiments, the compositions contain additional agents, including biological agents.

Flowable collagen-based hemostat and methods of use

The present invention relates to a method of preparing a bioactive composite, the method comprising the steps of a) adding in a solid state a biocompatible polymer and a bioactive glass to an extruder to form an extrudable material; b) applying energy to the extrudable material to at least the melting temperature of the biocompatible polymer to melt mix the biocompatible polymer and bioactive glass; and c) extruding a bioactive composite.

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Philadelphia, PA, United States of America

Marissa M Conrad