George Mason University

Marissa A Howard

Lance A Liotta

Alessandra Luchini Kunkel

Amanda Haymond Still

Ish Sethi

Rachel Naidich

Rebecca Woodhouse

Kshamata Neupane

Matthew Luu Trang

Virginia Espina

Hannah Elizabeth Steinberg

Sameen Yusuf

Ngoc Bao Vuong

Sara Sharif

Kelsey Mitchell

Amanda Lynn Still

Ghaliah Abdraboh M Alluhaibi

An embodiment relates to a reagent buffer comprising a zwitterionic sulfonic solution, a non-ionic surfactant solution, and a buffer solution, wherein the reagent buffer has a pH range of about 7.0 to about 8.0 and a circular dichroism with an absorbance peak more than 0 at 190 nm and 225 nm. In an embodiment, the reagent buffer is configured to be a reagent buffer for a lateral flow immunoassay for detection of COVID-19.

Reagent buffer

A liquid including an organic component, a stabilization component, and a preservation component is provided. The organic component, the stabilization component, and the preservation component are different components. The organic component present in the liquid includes a volatile organic solution with a refractive index of 1.5 or below. Further, the liquid is a visualization solution that provides a resolving power of a lens by 1/1.5.

Laser capture microdissection visualization chemistry

A wearable device measures, tracks, and monitors a wearer's physical physiological conditions during a rehabilitation period. Metrics such as temperature, patellar shifting, limb circumference, and acceleration may be collected. Changes in monitored conditions may be assessed for detecting medical abnormalities which require specialized attention, including for example embolisms or infections. A networked communication system and various user interfaces may be used for medical support personnel and patients alike to stay updated with the patient's rehabilitation progress and to make adjustments in a patient's individual rehabilitation program.

Non-invasive wearable biomechanical and physiology monitor for injury prevention and rehabilitation

A collapsible sample collection device with a novel, collapsible 3D capture open affinity net dispersed throughout the volume of the container, said net with tethered affinity moieties, is designed to address the need for low-cost, simple harvesting and concentration of diagnostic analytes that generally does not require any ancillary equipment. The collection device generally permits analytes of interest to be efficiently harvested from body fluid samples, in one step, concentrated, collapsed into a flat mailing size, and protected from degradation without the need for traditional cold chain technologies. The concentration factor will increase sensitivity by several orders of magnitude when coupled with any type of downstream analyte measurement, including point of care testing. The collection device, in various embodiments, obviates the need for handling transport or storage of the fluid portion of the body fluid sample (e.g. blood, urine, saliva, etc.) with a volumetric concentration factor of 5 to 100 fold. The collapsed collection device generally may be mailed to a laboratory for analysis via any chemical, immunological, electrical or other analytical methods.

Collapsible fluid collection system for point-of-care diagnostics

Growing community of inventors

Richmond, VA, United States of America

Marissa A Howard