Neurotune Ag

Teva Pharmaceuticals International Gmbh

Pliva Hrvatska D.o.o.

Marisa Martinelli

Carla Ghelardini

Carlo Parini

Carlo Farina

Stefania Gagliardi

Pavel Kolesa

Maurizio Paiocchi

Piero Paravidino

Paolo Simone Tiseni

Silvano Ronzoni

Donato Motolese

Roberta Volonté

Matteo Toso

Roberta VolontÉ

Disclosed crystalline Siponimod fumaric acid, solid state forms (polymorphs) thereof, processes for preparation thereof and pharmaceutical compositions thereof.

Crystalline siponimod fumaric acid and polymorphs thereof

The present disclosure relates to Plinabulin solid state forms, Plinabulin salts including hydrochloride and solid state forms thereof, processes for preparation thereof and pharmaceutical compositions thereof. 

Salts and solid state forms of plinabulin

The invention refers to compounds of general formula (I) wherein the R groups are, independently, H, Calkyl, aryl, CF; Y is CH, C&#x2550;O; X is bond, C&#x2550;O, SO, or C&#x2550;N&#x2014;CN; m is 0, 1; n is 0, 1; A is a heterocycle, or a phenyl group optionally substituted as defined in the specification. The compounds are active on chronic pain conditions of different origin; they can be administered alone or with other drugs. Most of these compounds are new. The invention include a process to prepare said compounds, and pharmaceutical compositions suitable for their administration to a patient. 

Substituted pyrrolo[1,2-A] pyrazines, compositions containing these, processes of making these, and uses thereof

Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof

Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents

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Villa Guardia, Italy

Marisa Martinelli