Crinos Industria Farmacobiologica S.p.a.

Marisa Maontovani

Giuseppe Prino

Gianfranco Fedeli

Giuseppe Diamantini

By carrying out the depolymerization of stabilized solutions of highly polymerized and nicked polydeoxyribonucleotides, as obtained through stabilizing aggregation of raw nucleic acids, the depolymerization being carried out by heating at controlled temperature and being controlled as a function of the variation of the reversible hyperchromicity, followed by the removal of the hydrogen bonds in the double stranded filaments and by thermal stabilization of the single stranded filaments, the polydeoxyribonucleotide, known as Defibrotide is obtained. Defibrotide has the following formula of random sequence:

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Villas Guardia, Italy

Marisa Maontovani