Gruppo Lepetit

Marisa Berti

Renato Cricchio

Novel 4-desoxy-thiazole[5,4-c]rifamycin derivatives of formula I ##STR1## wherein R stands for a group --OR.sub.1, --NR.sub.2 R.sub.3 or --NHCOR.sub.4 wherein R.sub.1 represents alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl, R.sub.2 and R.sub.3 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl or R.sub.2 and R.sub.3 taken together with the adjacent nitrogen atom may represent a 5 to 7 membered heterocyclic ring and R.sub.4 is a radical selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl; R.sub.5 is hydrogen or acetyl; and a process for preparing them. The novel compounds have an antibacterial utility.

Process for preparing 4-desoxy-thiazolo[5,4-c]rifamycin derivatives

Novel 4-desoxy-thiazolo[5,4-c]rifamycin derivatives of formula I ##STR1## wherein R stands for a group --OR.sub.1, --NR.sub.2 R.sub.3 or --NHCOR.sub.4 wherein R.sub.1 represents alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl, R.sub.2 and R.sub.3 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl or R.sub.2 and R.sub.3 taken together with the adjacent nitrogen atom may represent a 5 to 7 membered heterocyclic ring and R.sub.4 is a radical selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl; R.sub.5 is hydrogen or acetyl; and a process for preparing them. The novel compounds have an antibacterial utility.

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Milan, Italy

Marisa Berti