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Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr

Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi

Institu Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr

Maris M Veveris

Ivars Y Kalvinsh

Gunar Y Dubur

Agris A Kimenis

Egils A Biseniex

Yan R Uldrikis

Edmund Y Lukevits

Gunar A Bremanis

Irene B Antsena

Anatoly S Birman

Valeryans Y Kauss

Valdis D Mikazhan

Marina L Erenshtein

Inna I Makarova

Petr T Trapentsier

Evgeny V Ivanov

Edvards E Liepinsh

Alexei V Vinogradov

Oleg N Akifiev

Georgy V Barmotin

Peter T Trapentsier

Natalia V Barmenkova

Edit A Pule

Yanis J Polis

Edvard E Liepinsh

Natalya V Makarova

Novel compounds, that is, alkoxy- and phenoxy-alkyl esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxy li c acid have the following general formula useful for producing hypotensive and vasodilation effects. ##STR1##

Alkoxy-and phenoxy alkyl esters of

Novel compounds, viz. 3-(2,2,2-trisubstituted hydrazinium) propionates have the following general formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are an alkyl, a substituted alkyl, a substituted or unsubstituted aryl, an aralkyl or an unsaturated alkyl;

3-(2,2,2-trisubstituted hydrazinium) propionates

Substituted 3-hydrazinopropionates comprising compounds of the general fola: ##STR1## wherein R.sup.1, R.sup.2 =H, an alkyl, a substituted alkyl, hydroxycarbonyl, alkoxycarbonyl, an aryl, an aralkyl, an unsaturated alkyl, a substituted aryl or a substituted aralkyl: ##STR2## wherein R.sup.7, R.sup.8 =H, an alkyl, an unsaturated alkyl, an aralkyl, an aryl, a substituted alkyl,

Substituted 3-hydrazinopropionates

A novel pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction, which comprises as an active ingredient, (1,1-dimethyl-3-oxopyrazolidin-1-io-4-yl)acetate of the following formula: ##STR1## and a pharmaceutically acceptable vehicle.

Pharmaceutical preparation for the treatment of hypertensive disease and

A compound 2,6-dimethyl-3,5-bis-(1-adamantylhydroxycarbonyl)-4-(2-difluoromethoxyphen yl)-1,4-dihydropyridine of the formula ##STR1## is proposed. Said compound possesses antianginal activity.

2,6-Dimethyl-3,5-bis-(1-adamantylhydr

2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide) glutaric acid of formula I and its disodium salt of formula II ##STR1## Said acid is obtained from glutaminic acid and dimethyl 3,5-diethoxycarbonyl-1,4-dihydroisonicotic acid. For obtaining disodium salt, said acid is reacted with a caustic soda solution. These compounds possess antiarrhythmic activity.

2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide

A pharmaceutical composition for the treatment of cardio-vascular diseases comprising 3-(2,2,2-trimethylhydrazinium) propionate dihydrate of the following formula:

Treatment of cardio-vascular diseases with

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Maris M Veveris