Praxis Precision Medicines, Inc.

Marion Wittmann

Kiran Reddy

Gabriel Martinez Botella

Brian Edward Marron

Andrew Mark Griffin

Margaret S Lee

Mahesh Padval

Randall Wagner

Gabriel Maurice Belfort

Sapna Makhija Garad

Described herein, in part, are dosage forms and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel.

Formulations of T-type calcium channel modulators and methods of use thereof

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Ion channel modulators

Growing community of inventors

Medford, MA, United States of America

Marion Wittmann