Forschungszentrum Julich Gmbh

Marion Thust

Hans Luth

Michael Josef Schoning

Peter Kordos

Michael Gotz Berger

Ulrich B Kaupp

Rudiger Arens-Fischer

Claus-Dieter Kohl

Stephan Frohnhoff

Axel Schwarz

Bernhard Weissbecker

Hans Hummel

Armin Riemer

Joachim Vetter

Stefan Schutz

In a biosensor system for detecting trace compounds resulting from a fire or from plants damaged by destructive insects, a live chemoreceptor is provided for sensing the trace compounds, and a semiconductor component is connected to the chemoreceptor for providing sensor signals when the chemoreceptor senses the presence of trace compounds.

Biosensor system for detecting organic trace compounds produced by

Biomaterial such as an enzyme, cell, antigen or antibody is immobilized by covalent bonding to a substrate having an Si.sub.3 N.sub.4 surface containing Si--NH.sub.2 groups that provide reactive NH.sub.2 groups. A heterobifunctional cross-linking agent having an NH.sub.2 -reactive group and a biomaterial-reactive group is reacted with the NH.sub.2 groups of the surface and then with the biomaterial or the heterobifunctional cross-linking agent is reacted with the biomaterial and then with the NH.sub.2 groups of the surface. The Si.sub.3 N.sub.4 surface containing Si--NH.sub.2 groups can be formed by precipitating on a substrate a 10-1000 nm thick Si.sub.3 N.sub.4 layer from a SiH.sub.4 /NH.sub.3 mixture, and providing reactive NH.sub.2 groups on the surface of the layer by subjecting the surface to hydrolyzing cleaning.

Biomaterial immobilization on an Si.sub.3 N.sub.4 surface containing

Chemical sensors, in particular silicon-based biosensors

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Koln, Germany

Marion Thust