Rutgers, The State University of New Jersey

Lehigh University

Marion K Gordon

Jeffrey D Laskin

Patrick J Sinko

Ned D Heindel

Diane E Heck

Carl Jeffrey Lacey

Manjeet Deshmukh

Anupa R Menjoge

Abhilash N Pillai

Siva N Priya Anumolu

Formulations of cross-linkable polymers, capable of forming non-toxic and biocompatible hydrogels in situ, containing at least one of doxycycline or minocycline. Methods of using the hydrogels for treating the skin or ocular tissues of mammals exposed to vesicant compounds such as sulfur mustard (SM), nitrogen mustard (NM) or half mustard (2-chloroethyl ethyl sulfide (CEES)) are also disclosed.

Hydrogel formulation for dermal and ocular delivery

Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic moiety. Also disclosed are direct syntheses of these vanilloid fatty hydroxamates. The compounds possess inhibitory activity against the enzymes fatty acid amide hydrolase (FAAH) and matrix metallo-proteinase 9 (MMP-9). In addition, these substances bind to the calcium channel protein TRPV1 and inhibit vesicant-induced inflammation in skin and cornea. The compounds have utility in treating topical or systemic inflammatory processes in the skin and/or eye.

Vanilloid fatty hydroxamates as therapeutic anti-inflammatory pharmaceuticals

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Princeton, NJ, United States of America

Marion K Gordon