Bayer Intellectual Property Gmbh

Bayer Pharma Aktiengesellschaft

Ardea Biosciences, Inc

Marion Hitchcock

Gerhard Siemeister

Hans Briem

Simon Holton

Anne Mengel

Amaury Ernesto Fernandez-Montalvan

Knut Eis

Wilhelm Bone

Jens Schröder

Philip Lienau

Mark Jean Gnoth

Ursula Mönning

Anja Richter

Cornelia Preuβe

Lars Bärfacker

Volker Schulze

Stefan Prechtl

Florian Pühler

Vera Pütter

Antje Margret Wengner

Ingo Hartung

Jörg Fanghänel

Cornelia Preusse

Ulrich Klar

Ulf Bömer

Jean-Michel Andre Vernier

Thomas Ernst Müller

Hans-Georg Lerchen

Ludwig Zorn

Joachim Kuhnke

Arne Scholz

Arwed Cleve

Shunqi Yan

Roland Neuhaus

Christoph-Stephan Hilger

Helmut Sonnenschein

Judith Günther

Keith Graham

Christian Stegmann

Heinz Graubaum

Florian Puehler

Hong Woo Kim

Manfred Möwes

René Tempel

Jozsef Bálint

Amaury Ernesto Fernández-Montalván

Ulf BÖMER

Lars BÄRFACKER

Florian PÜHLER

Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.

Substituted benzylindazoles for use as BUB1 kinase inhibitors in the treatment of hyperproliferative diseases

Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals. 

3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones

Compounds of formula (I) as defined herein and their use as pharmaceuticals. 

Benzyl substituted indazoles as BUB1 inhibitors

Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases

Compounds of formula (I), and their use as pharmaceuticals. 

Substituted benzylpyrazoles

Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals. 

Heteroaryl substituted pyrazoles

Compounds of formula (I), processes for their preparation and their use as pharmaceuticals. 

Compounds of formula (I) and their use as pharmaceutical. 

The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I): in which A, R1, R3 and n are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients. 

Amino-substituted imidazopyridazines

Substituted N-(2-arylamino)aryl sulfonamide-containing combinations

The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients. 

Substituted phenoxypyridines

The present invention relates to substituted sulphonamido phenoxybenzamide compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined in the claims, to pharmaceutical compositions and combinations containing said compounds, to methods of preparing said compounds, and to the use of said compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.

Substituted sulphonamido phenoxybenzamides

The present invention relates to substituted benzosulphonamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients. 

Substituted benzosulphonamides

This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N'-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases.

Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors

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Berlin, Germany

Marion Hitchcock