Georgia Tech Research Corporation

Marion Gabriele Gotz

James C Powers

Juliana Asgian

Karen Ellis James

Brian Rukamp

Özlem Dogan Ekici

Zhao Zhao Li

The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure include peptidyl allyl sulfone compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro.

Peptidyl allyl sulfones

The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure include a peptidyl propenoyl hydrazide compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro.

Propenoyl hydrazides

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Marion Gabriele Gotz