Institut National De La Sante Et De La Recherche Medicale

Université Paris—sud

Alfact Innovation

Assistance Publique-Hopitaux De Paris

Université Paris Diderot-Paris 7

Institut National De La Recherche Agronomique (Inra)

Inserm

The Healthy Aging Company

Marion Darnaud

Christian Bernard Brechot

Laure Jamot

Jamila Faivre

Gilles Amouyal

Paul Amouyal

Joël Dore

Eric Vibert

Christophe Magnan

Nicolas Moniaux

Fabrizio Andreelli

Celine Cruciani-Guglielmacci

Jamila Vaivre

Céline Cruciani-Guglielmacci

The invention concerns a Reg3&#x3b1; polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for use in the protection of oxygen sensitive gram-positive bacteria, compositions comprising the polypeptide and their use. The inventors have shown that an increase in the concentration of the h Reg3&#x3b1; lectin into the gastrointestinal tract (GIT) lumen of hReg3&#x3b1;-transgenic mice induced significant changes in the composition of the gut microbiota, and dramatically improved host resistance to intestinal inflammation. hReg3&#x3b1; exerted a potent antioxidant activity on intestinal epithelial cells during colitis, and in particular the ROS scavenging activity, in particular, by promoting the survival of highly oxygen sensitive bacteria. Inventors also showed that h Reg3&#x3b1;-transgenic mice resist better to DSS-induced colitis after antibiotherapy. Thus, the invention concerns a Reg3&#x3b1; polypeptide for use in the protection of oxygen sensitive gram-positive bacteria, notably the Ruminococcaceae, such as, and/or the Lachnospiraceae, such as; pharmaceutical compositions comprising the polypeptide and their use; and the use of this polypeptide for promoting ex vivo growth of oxygen sensitive gram-positive bacteria. The Reg3&#x3b1; polypeptide may be used for preventing or treating microbiota-related disease and/or disorder, particularly selected from inflammatory bowel disease (IBD), colitis, gastrointestinal infections, irritable bowel syndrome and other gastrointestinal functional diseases, gastrointestinal tract cancer, metabolic syndrome and obesity, diabetes, liver diseases, allergic diseases, neurodegenerative diseases and psychological disorders.

Polypeptide for use in the protection of oxygen sensitive gram-positive bacteria

The invention relates to a HIP/PAP protein or to one of the derivatives thereof for use thereof for treating or preventing insulin resistance in non-insulin dependent subjects.

Composition including the HIP/PAP protein or one of the derivatives thereof for treating insulin resistance

This invention concerns a HIP/PAP protein or derivative thereof, for its use in treating or managing cancer and preferentially solid tumors.

HIP/PAP protein and derivatives thereof for use in treating cancer

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Paris, France

Marion Darnaud