Pharmacia Italia S.p.a.

Pharmacia Corporation

Mario Ungari

Attilio Tomasi

Giuliano Ramella

Stefania Magenes

Marco Pandolfi

Gianfranco Pallanza

Ilaria Candiani

Raffaella Budelli

A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals. A new solvate form V of cabergoline, useful as an intermediate, is also provided.

Process for preparing crystalline Form I of cabergoline

Crystalline form II of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise crystallization from s solution of raw cabergoline in an organic solvent at low temperatures or submitting to a slurry procedure a mixture of cabergoline forms I and II in a solvent at a temperature below 30&deg; C.

Crystalline form II of cabergoline

Process for preparing crystalline form I of cabergoline

Crystalline form VII of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise a slurry procedure using form I or mixture of forms I and VII of cabergoline in a solvent at a temperature above 30&deg; C.

Crystalline form VII of cabergoline

Crystalline form II of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise crystallization from a solution of raw cabergoline in an organic solvent at low temperatures or submitting to a slurry procedure a mixture of cabergoline Forms I and II in a solvent at a temperature below about 30&deg; C.

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Milan, Italy

Mario Ungari