Wisconsin Alumni Research Foundation

Mario Otto

Jamey Paul Weichert

Bryan P Bednarz

Anatoly Pinchuk

Paul M Sondel

Zachary Scott Morris

Peter Carlson

Dana C Baiu

Chorom Pak

Benjamin Titz

Fotis Asimakopoulos

Roberta Marino

Kevin R Kozak

Jamie Weichert

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and Ris —N(CH). The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, Rincludes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, Rincludes a detection moiety, such as a fluorophore or a radioactive iodine isotope.

Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors

A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein Ris a radioactive halogen isotope, n is 18 and Ris —N(CH).

Radiohalogenated agents for in situ immune modulated cancer vaccination

The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula: wherein Rcomprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and Ris &#x2014;N(CH).

Targeted radiotherapy chelates for in situ immune modulated cancer vaccination

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and Ris &#x2014;N(CH). The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, Rincludes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, Rincludes a detection moiety, such as a fluorophore or a radioactive iodine isotope.

A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein Ris a radioactive halogen isotope, n isand Ris &#x2014;N(CH).

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and Ris &#x2014;NH, &#x2014;NHX, &#x2014;NHX, or &#x2014;NHX, wherein each X is independently &#x2014;CHor &#x2014;CH. The compounds can be used to treat multiple myeloma or to detect multiple myeloma. In therapeutic treatment, Rincludes a radionuclide that locally delivers therapeutic dosages of radiation to the multiple myeloma tumors cells that preferentially take up the compound. In detection/imaging applications, Rincludes a detection moiety, such as a fluorophore or a radiolabel.

Growing community of inventors

Fitchburg, WI, United States of America

Mario Otto