Polifarma S.p.a.

Other

Mario Materazzi

Giovanni Di Stazio

Giovanna De Luca

Vincenzo Politi

Andrea Margonelli

Silvana D'Alessio

Vencenzo Politi

Giovanna DeLuca

Giovanni DiStazio

Vincenzo Polita

Peptidomimetic compounds capable of inhibiting zinc-dependent metalloproteinases to treat pathological conditions associated with activation of endogenous metalloproteinases in mammals.

Inhibitor compounds of zinc-dependent metalloproteinases associated with

A method for determining the therapeutic potential of peptidomimetic compounds as inhibitors of zinc-dependent metalloproteinase activity associated with pathological conditions of humans and animals.

Method for determining the therapeutic activity of metalloproteinase

3-indolepyruvic acid is an active agent in preventing cerebral damage caused by stress and ageing and induced by an excessive presence in the blood of glucocorticoids, secreted by the adrenal gland.

Method for reducing the level of glucocorticoids in the blood and

3-indolepyruvic acid derivatives substituted on the benzene moiety show good antagonizing activity on excitatory aminoacids and on free radicals, for which reason they are therapeutic agents in cerebral and peripheral degenerative pathologies. Their method of production by passage through the corresponding substituted triptophane.

Tryptophane and 3-indolepyruvic acid, methods of production therefor

Uridine is used to treat the peripheral complications of diabetes, such as neuropathy, retinopathy and vasculopathy, thanks to its characteristics of promotor of glycogen endocellular biosynthesis. 40 diabetic patients were treated for six months with uridine or with placebo in a double-blind clinical teat.

Use of uridine in the pharmacological treatment of the peripheral

Compounds of peptide nature presenting a sequence of three aminoacids, in particular with PYR and TRP as terminal groups, are found to be active as immunomodulating agents.

Method of treatment with tripeptide pharmaceutical compositions as

A description is given of the cosmetic use of 3-indolepyruvic acid for the protection of the skin from damage caused by oxygen, by the sun and by aging.

Cosmetic use of 3-indolepyruvic acid

Indolepyruvic acid shows an inhibitory activity with respect to the degenerative action by oxygen free radical which are responsible for a number of pathologic conditions in various peripheral tissues. The compound can find application in miocardiopathies, inflammations, circulatory shock, arteriosclerosis, and cardiac ischemia.

Use of 3-indolepyruvic acid as a pharmaceutical agent for the inhibition

3-indolepyruvic acid derivatives and pharmaceutical use thereof

Disorders due to an altered balance of dopamine release by the cerebral dopaminergic system, such as schizophrenia and Parkinson's disease, can be treated by administration of uridine which is a specific agent for the protection of the cholecystokinin level in the brain tissue.

Pharmacological use of uridine in the treatment of nervous disorders

Production of indolepyruvic acid and the 5-hydroxy derivative thereof

Thirteen new tripeptides made from levorotatory amino acids are described, corresponding to the formula

Tripeptide compounds containing pyroglutamic acid and tryptophan,

The process for the biosynthesis of 3-indolpyruvic acid involves the reaction of tryptophan with purified enzyme aspartate aminotransferase obtained from the mytochondria of slaughterhouse animals. When administered orally in rats, 3-indolpyruvic acid leads to a considerable increase in cerebral serotonin levels, and so may be used in all the pathological conditions of the central nervous system involving deficiencies of this neurotransmitter, such as depressions, insomnia, lack of appetite, neuroendocrin imbalances, etc.

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Rome, Italy

Mario Materazzi