Farmitalia Carlo Erba S.r.l.

Pharmacia & Upjohn S.p.a.

Mario Ferrari

Anna Maria Isetta

Gianfederico Doria

Domenico Trizio

Maria C Fornasiero

Rinaldo Ferreccio

Francesco Colotta

Marcellino Tibolla

Alberto Bargiotti

Roberto D'Alessio

Ermes Vanotti

Paola Gnocchi

Roberto D&prime;Alessio

MariaChiara Fornasiero

AnnaMaria Isetta

Benzyloxy prodigiosine compounds

A product containing: (a) an immunosuppressant agent (A) and (b) at least one immunosuppressant 2,2&prime;-bi-1H-pyrrole compound (B) having formula (I) wherein R,is hydrogen, phenyl, C,-C,alkyl or C,-C,alkenyl, wherein the alkyl and alkenyl groups are unsubstituted or substituted by 1 to 3 substituents, which are the same or different, chosen independently from halogen, C,-C,alkoxy, hydroxy, aryl and aryloxy; R,is hydrogen, C,-C,alkyl, cyano, carboxy or (C,-C,alkoxy)carbonyl; R,is halogen, hydroxy or C,-C,alkoxy unsubstitued or substituted by phenyl; R,is hydrogen, C,-C,alkyl or phenyl; each of R,and R,, which are the same or different, is independently hydrogen, C,-C,alkanoyl, C,-C,alkenoyl, phenyl, C,-C,alkyl or C,-C,alkenyl; or two of R,, R,and R,, taken together, form a C,-C,polymethylene chain, which is unsubstituted or substituted by a C,-C,alkyl, by a C,-C,alkenyl or by a C,-C,alkylidene group; or a pharmaceutically acceptable salt thereof; as a combined preparation for simultaneous, separate or sequential use in immunosuppressant therapy, said preparation having a potentiated immunosuppressive activity with respect to products containing either the immunosuppressive agent (A) or the 2,2&prime;-bi-1H-pyrrole immunosuppressive compound (B).

Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole compound

Indolyl-pyrrolydenemethylpyrrole derivatives and process for their

Pyrrolydenemethyl-derivatives and process for their preparation

Condensed pyrazole 3-oxo-propanenitrile derivatives

This invention relates to a method of treating rheumatoid arthritis, which method comprises administering to a mammal a therapeutically effective amount of a compound of formula (I): ##STR1## wherein R1 is unsubstituted or substituted phenyl;

Morphalinomethyl-substituted 1-phenyl-indero-[1,2-c]pyrazol-3-yl

Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R.sub.4)--, --O--CH(R.sub.4)--, --S(O).sub.n --CH(R.sub.4)--, --CH(R.sub.4)--O--, --CH(R.sub.4)--S(O).sub.n -- or --CH(R.sub.4)--CH.sub.2 -- group wherein n is 0, 1 or 2; R.sub.1 represents C.sub.1 -C.sub.6 alkyl, pyridyl or unsubstituted or substituted phenyl; R.sub.2, R.sub.3, and R.sub.4 are as herein defined; and Q is hydrogen, carboxy, C.sub.2 -C.sub.7 -alkoxycarbonyl or a --CON(R.sub.a)R.sub.b group, R.sub.a and R.sub.b being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the

Use of heteroaryl-3-oxo-propanenitrile derivatives in treating clinical

Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R.sub.4)--, --O--CH(R.sub.4)--, --S(O).sub.n --CH(R.sub.4)--, --CH(R.sub.4)--O--, --CH(R.sub.4)--S(O).sub.n -- --CH(R.sub.4)--CH.sub.2 -- group wherein n is 0, 1 or 2; R.sub.1 represents C.sub.1 -C.sub.6 alkyl, pyridyl or unsubstituted or substituted phenyl; R.sub.2, R.sub.3, and R.sub.4 are as herein defined; and Q is hydrogen, carboxy, C.sub.2 -C.sub.7 -alkoxycarbonyl or a --CON(R.sub.a)R.sub.b group, R.sub.a and R.sub.b being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of

Tricyclic 3-oxo-propanenitrile derivatives

The invention relates to compounds having the general formula (I) ##STR1## and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.

Condensed pyrazole derivatives, pharmaceutical compositions and use

The invention relates to compounds having the general formula (I) ##STR1## wherein n is zero, 1 or 2;

Cinnoline-carboxamides and process for their preparation

Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions

Growing community of inventors

Milan, Italy

Mario Ferrari