Proter S.p.a.

Tirsi S.r.l.

Mario Ercole Scevola

Germano Coppi

Leone Dall'Asta

Vanna Springolo

Marco Gioacchino Delle Canne

Manuela Spagnol

A therapeutic treatment for the athrosis diseases comprising administering by intraarticular route from 1 to 5 ml of an aqueous solution containing from 10 to 50 mg of a diacetyl rhein salt having formula (I): ##STR1## wherein M represents an alkali or an earth alkali metal or the residue of an organic base. The diacetyl rhein salts administered by intraarticular route exhibit higher pharmacological activity than the corresponding diacetylrhein administered orally.

Diacetylrhein salts and their therapeutical use in the treatment of

Several methods are disclosed for the preparation of oral pharmaceutical forms with delayed release of rhein and its derivatives. The pharmaceutically active ingredient is provided in the form of granules, coated with at least one of polyvinylpyrrolidone, shellac and hydroxypropylmethyl cellulose. The desired effect of the coating is to slow release of the pharmaceutically active ingredient by resisting gastric juices in the stomach, but gradually dissolving in the intestines.

Galenic formulations for oral use of rhein derivatives with delayed

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Milan, Italy

Mario Ercole Scevola