Altergon Sa

Indena S.p.a.

E-l Management Corporation

Development Biotechnological Processes S.n.c Di Pelliccia Maria Teresa

Gibipharma S.p.a.

Mitani Group, Inc.

Msb S.r.l.

Pharmaphelix S.r.l.

Centro Interuniversitario Di Ricera Sui Peptidi Bioattivi-universita'

Consorzio Per La Gestione Del Centro Di Biotecnologia Avanzata

Arval S.p.a.

Kaleyde Pharmaceuticals Ag

Mario De Rosa

Chiara Schiraldi

Mosè Rossi

Vincenzo Pavone

Vincenzo Zappia

Cesare Ponzone

Carlo Pedone

Ranieri Cancedda

Maria Vincenza Carriero

Angelina Lombardi

Michele De Luca

Alessandra Morana

Emiliano Bedini

Antonella Di Lazzaro

Graziella Pellegrini

Antonella D'Agostino

Annalida Di Nola

Giuseppe Geraci

Cristina De Castro

Michelangelo Parrilli

Annalisa La Gatta

Mirela Mitan

Odile Francesca Restaino

Donatella Cimini

Antonella D'agostino

The present invention relates to the use of chondroitin as a transdermal carrier and slow-release system for active ingredients in pharmaceutical and cosmeceutical compositions.

Chondroitin complexes for transcutaneous absorption

A cytomimetic formulation is provided comprising at least two of: (a) a fermented truffle extract; (b) a plurality of hyaluronic acids of different molecular weight, ranging from 50 KDa up to 2000 KDa; (c) an olive leaf extract in a mineral-containing water; and (d) a fermented grape must. The formulations mimic the skin cytoplasmic environment and create optimal conditions for cellular growth and skin rejuvenation. Methods of use and processes for manufacturing thereof are also provided.

Cytomimetic formulations and methods of manufacturing the same

Describes cooperative hybrid complexes of hyaluronic acid, a simple and economical method for production thereof and use thereof in the area of medicine, cosmetics and food.

Hybrid cooperative complexes of hyaluronic acid

The present invention relates to a downstream industrial method of purifying chondroitin sulphate obtained from animal cartilage, which produces a product fully compliant with the specifications required for the use of said compound in the pharmaceutical field.

Chondroitin sulphate purification method

Chondroitin, a metabolic intermediate of chondroitin sulphate biosynthesis in mammals and other living organisms, possesses biological properties different from those of chondroitin sulphate, and can be advantageously used for applications in the pharmaceutical, nutraceutical, cosmeceutical and medical device fields. Chondroitin has biostimulating, anti-inflammatory and anti-microbial activity and can be used in the treatment of osteoarthritis, eye disorders, interstitial cystitis, lung disorders, inflammatory disorders in general, oncological disorders, peritoneal dialysis, tissue biorevitalisation and wound repair, as a skin filler, and as bioresorbable scaffolds.

Chondroitin for use in medicine

Disclosed is a process for the production of chondroitin sulphate, wherein N-acetyl-galactosamine residues sulphated at the 4- or 6-positions are present on the same polysaccharide chain.

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A composition, a method, and a kit are provided for chemical skin peeling, based on nano-structured thixotropic inorganic gels, which have a higher potency and are less irritant of the conventional peeling formulations. The gels of the invention can easily be applied on the skin, where they form a stable, uniform layer, that doesn't strain. The kit comprises by a defatting gel, different types of peeling gels and a neutralizing gel. The defatting gel is characterized by a markedly enhanced defatting capacity in comparison to the conventional products, because the sebum solubilized by the solvent is strongly adsorbed on the huge surface of the nano-structured material of the gel. The peeling gels are based on conventional peeling compounds, such as glycolic acid, trichloroacetic acid, pyruvic acid, salicylic acid, Jessner solution, but the presence of nano-structured material strongly increases the peeling effect, allowing the use of lower concentrations of peeling compound, with only minimal skin irritation for the user. The neutralizing gel is characterized by a color change that allows the operator to verify in real time the neutralization of the peeling agent on the treated skin surface. All the gels of the invention can be easily removed from the skin after the treatment. The thixotropic gels of the invention can be used in chemical skin peeling for the treatment of various cosmetic conditions and dermatological disorders, including dry skin, acne, dandruff, keratoses, age spots, wrinkles and disturbed keratinization.

Nano-structured thixotropic inorganic peeling gels

An innovative method is described for the production of chondroitin at high concentration, by fermentation of genetically mutated bacteria.

Biotechnological production of chondroitin

Peptides and their functionally equivalent derivatives, in salt form or non-salt form, effective in the treatment and prevention of tumor, with the general formula L-X-X-X-X, wherein: Lis H, or acyl, or any natural or non-natural amino acid; Xis any natural or non-natural amino acid, optionally N-alkylated and/or C&#x3b1;-alkylated; Xis any natural or non-natural hydrophobic amino acid, optionally C&#x3b1;-alkylated and/or amidated at the C-terminal end, or any hydrophobic amino alcohol, or a hydrophobic gem-diamine, optionally N'-alkylated or N&#x2032;-acylated.

Peptides having pharmacological activity for treating disorders associated with altered cell migration, such as cancer

A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis ofsteroid glycosides (ruscosaponins) by means of crude hydrolases from

Process for the preparation of derivatives of Ruscus aculeatus steroid glycosides by enzymatic hydrolysis

The present invention relates to a liquid, substantially anhydrous eutectic mixture comprising a principal acid component, such as a hydroxy acid, and at least one other component selected from the group consisting of a carbohydrate, a polyol, an amino acid, and a carboxylic acid. The mixtures remain liquid at room temperature, are relatively non-irritating, and can be used to deliver higher levels of the principal acid than would ordinarily be possible. The invention also provides a method of making such a mixture comprising heating the component having the lowest melting point to the temperature at which it melts, dissolving the remaining component or components in the melted component, and allowing the mixture to cool.

Eutectic mixtures in cosmetic compositions

Soluble tachykinin antagonists, the preparation and use thereof

Cryoprotective aqueous solutions useful for the preservation of in vitro

Cosmetic preparations containing ubidecarenones

Stable salts of S-adenosyl-L-methionine with water-soluble polyanions, such as polyphosphates, polyvinylsulfonates -sulfates or -phosphates, polyacrylates, polystyrene sulfonates, are described. The salts according to the invention, prepared by precipitation from aqueous solutions of pH not exceeding 3.5, possess peculiar stability, solubility, nonhygroscopicity and are valuable for use as active constituents in pharmaceutical compositions.

Stable salts of S-adenosyl-L-methionine with polyanions

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Naples, Italy

Mario De Rosa