Istituto De Angeli S.p.a.

Dr. L. Zambeletti Spa

Karl Thomae Gesellschaft MIT Beschrankter Haftung

Dr. L.sup.o. Zambeletti, S.p.a.

Instituto De Angeli S.p.a.

Mario Bergamaschi

Enzo Cereda

Arturo Donetti

Piero Del Soldato

Vittorio Vecchietti

Gunther Schmidt

Massimo Signorini

Gian B Gervasi

Carlo Alfieri

Novel compounds of formula ##STR1## are described which have antipyretic, analgesic and antiinflammatory activity. R is hydrogen, C.sub.1 -C.sub.3 linear or branched alkyl; R.sub.1 and R.sub.2 are hydrogen, halogen, unsubstituted or esterified hydroxy, alcoxy, and may be the same or different; R.sub.3 is hydrogen, C.sub.1 -C.sub.4 linear or branched aliphatic acyl, unsubstituted or substituted aroyl, alkylaroyl or hetaroyl groups.

Biphenylylalkanoic acid derivatives, methods of preparation and

Pharmaceutical compositions suitable for the therapy of infected renal calculosis, containing propionhydroxamic acid as an active principle, are described.

Method for treating infected renal calculosis

This invention relates to imidazolylphenyl amidines, the preparation thereof, and pharmaceutical compositions containing them. More particularly, this invention relates to compounds of the general formula ##STR1## in which R, R.sub.1, and R.sub.3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group, and R.sub.2 represents a linear or branched alkyl, alkenyl, or alkynyl group, a cyano group, a hydroxyl group, a substituted or unsubstituted cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aralkyl or aryl group optionally substituted by halogen, methyl, methoxy, or methylenedioxy groups, or a substituted or unsubstituted heterocyclylalkyl or heterocyclic group which may also contain a further hetero atom, or a non-toxic, pharmacologically acceptable acid addition salt thereof. These compounds are useful in treating disorders of the gastrointestinal tract.

Imidazolylphenyl amidines

This invention relates to imidazolylphenyl amidines, the preparation thereof, and pharmaceutical compositions containing them. More particularly, this invention relates to compounds of the general formula ##STR1## in which R, R.sub.1, R.sub.3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group, and R.sub.2 represents a linear or branched alkyl, alkenyl, or alkynyl group, a cyano group, a hydroxyl group, a substituted or unsubstituted cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aralkyl or aryl group optionally substituted by halogen, methyl, methoxy, or methylenedioxy groups, or a substituted or unsubstituted heterocyclylalkyl or heterocyclic group which may also contain a further hetero atom, or a non-toxic, pharmacologically acceptable acid addition salt thereof. These compounds are useful in treating disorders of the gastrointestinal tract.

Imidazolylphenyl amidines, pharmaceutical compositions containing same

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl or ethyl;

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Monza, Italy

Mario Bergamaschi