Koninklijke Philips Corporation N.v.

Marinus Karel Johannes De Jager

Amir Hussein Rmaile

John Taylor

Philip Preshaw

Gerben Kooijman

Michael Alex Van Hartskamp

Supriyo Chatterjea

Rim Helaoui

Mark Thomas Johnson

Ronaldus Maria Aarts

Steven Charles Deane

Cornelis Petrus Hendriks

Vincent Jeanne

Caifeng Shan

Bart Gottenbos

Marco Baragona

Roland Alexander Van De Molengraaf

Valentina Lavezzo

Denny Mathew

Bart Jacob Bakker

Radu Serban Jasinschi

Milica Kovacevic Milivojevic

Yekaterina Borisenko

Aleksandro Grabulov

Sandra Hoetzl

Jayprakash Patel

Sandra HÖTZL

John J Taylor

Melissa Mackay Grant

Iain Leslie Campbell Chapple

Carl Glasse

Disclosed is a system, a kit, a use and an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The system and method are based on the insight to apply a clustering technique to a reference set of patient data, and then further discriminating the sets of bio markers to be applied. The clusters are determined on the basis of the biomarkers Hepatocyte Growth Factor (HGF), Matrix metalloproteinase 8 (MMP8), and Matrix metalloproteinase 9 (MMP9). The actual classification of the patient is done on the basis of the measurement of the concentrations of either of two sets of biomarkers. For one cluster these are Interleukin-1β (IL1β), Interleukin-6 (IL6), and Collagen Telopeptide. For the other cluster, these are HGF and metallopeptidase inhibitor 1 (TIMP1).

Classification of periodontitis patients

Disclosed is an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The method is based on the insight to determine a selection of three biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the proteins Interleukin-1β (IL-1β), Matrix metalloproteinase-9 (MMP-9) and at least one of the proteins: Interleukin-6 (IL-6), and Matrix metalloproteinase-3 (MMP-3). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of advanced periodontitis or of mild periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for mild periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for advanced periodontitis in said patient.

Diagnostics of mild or advanced periodontitis based on salivary IL-1BETA and MMP-9

Disclosed is an in vitro method for assessing whether a human subject has periodontitis. The method comprises detecting, in a sample of saliva from said subject, the concentrations of the proteins Hepatocyte Growth Factor (HGF) and Matrix Metalloproteinase 8 (MMP-8). Based on the concentrations determined, and adding age, and possibly other demographic markers such as sex and/or BMI, a testing value reflecting the joint concentrations is determined for said proteins, in combination with one or more demographic markers. The testing value is compared with a threshold value. The threshold reflects in the same manner the joint concentrations and the age, and possibly other demographic markers, as associated with periodontitis and may be seen as an upper limit of testing values as seen in a population of subjects without periodontitis. Thereby a testing value at or above the threshold value is indicative for periodontitis in said subject.

Diagnostics of periodontitis based on salivary HGF and MMP-8

A system for detecting halitosis is disclosed that comprises a gas sensor () for generating a sensor signal signalling the detection of compounds indicative of halitosis exhaled through an oral cavity; an image sensor () for capturing an image () of a dental condition and/or tongue condition in said oral cavity; and a processor () communicatively coupled to the gas sensor and the image sensor and adapted to process the sensor signal and the image in order to determine if in case of the sensor signal signalling the presence of a compound indicative of halitosis, said halitosis originates from said oral cavity by determining the dental condition and/or tongue condition in said image. A method for detecting halitosis and a computer program product implementing the method are also disclosed.

System and method for detecting halitosis

A method () for modifying a user's oral care program. The method includes the steps of: (i) providing () a network () comprising a first personal care device () in communication with a second personal care device (); (ii) cleaning () at least a portion of the oral cavity using the first personal care device; (iii) obtaining (), while cleaning with the first personal care device, sensor data for the at least a portion of the oral cavity; (iv) communicating () the obtained sensor data to the second personal care device; and (v) modifying (), based on the communicated sensor data, a function of the second personal care device.

Network for collaborating personal care devices

A nozzle () for an oral irrigator device () having a guidance tip () with an orifice at one end, and a dynamic nozzle actuator () positioned within said guidance tip. The orifice () is configured to expel a fluid as one of a jet, a spray, or any combination thereof. The dynamic nozzle actuator () comprises at least one responsive material adapted for being energized and configured to implement at least one dynamic actuation of an effective channel () for dynamically influencing at least one of (i) a direction of fluid expelled from the orifice (), (ii) an angle of fluid expelled from the orifice (), (iii) a cross-sectional width of fluid expelled from the orifice (), and (iv) any combination thereof.

Nozzle for oral irrigator device including a dynamic nozzle actuator with responsive materials

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Eindhoven, Netherlands

Marinus Karel Johannes De Jager