Southern Research Institute

Sanford-burnham Medical Research Institute

Marintha L Heil

Nicholas D P Cosford

Robert J Ardecky

Jiwen Zou

Peter Teriete

Nicholas Pagano

Nicholas Dp Cosford

Nicholas DP Cosford

Provided is a method for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus, as well as novel compounds that are useful in the method.

Quinazolinone analogs and use of quinazolinone analogs for treating or preventing certain viral infections

Provided is a process for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus. The process includes administering to the subject a therapeutically effective amount of at least one compound represented by the formula: (Formula (I)) 

Compounds of Formula (I) wherein B is selected from the group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; Y is a linker moiety selected from the group consisting of a direct bond. R, R1, R2, and R3 are each individually selected from the group consisting substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or heterocycle.

HIV replication inhibitors

Growing community of inventors

Frederick, MD, United States of America

Marintha L Heil