Tel Aviv University

Marina Zverzhinetsky

Fernando Patolsky

Vadim Krivitsky

Omri Heifler

A system for monitoring at least presence of a bioanalyte. The system comprises: a substrate having a skin contact surface, a microneedle outwardly protruding from the skin contact surface, a sensing complex positioned in the microneedle, and a circuit attached to the substrate. The sensing complex can comprise a nanostructure modified by a functional moiety covalently attached thereto, and an affinity moiety effective to react specifically with the bioanalyte to produce a reaction product. The circuit can apply voltage to the nanostructure and monitor changes in an electrical property of the nanostructure responsively to reaction between the reaction product and the functional moiety.

Method and system for subcutaneous sensing

A sensing system and a method utilizing same for determining and/or monitoring a presence and/or level of an analyte in a sample are provided. The sensing system is made of a nanostructure, or a plurality of nanostructures, having covalently attached thereto and a hydrogel having associated therewith a sensing moiety which selectively interacts with the analyte and being configured such that upon contacting the analyte, the nanostructure(s) exhibit a detectable change in an electrical property.

Methods and systems for detecting bioanalytes

A sensing element comprises a transistor having a gate electrode, a source electrode, a gate electrode and a semiconductor nanostructure connecting between the source and the gate electrodes. The semiconductor nanostructure is modified by a functional moiety covalently attached thereto. A voltage source is connected to the gate electrode. A controller controls a gate voltage applied by the voltage source to the gate electrode such as to reverse a redox reaction occurring when the moiety contacts a redox reactive agent.

Method and system for sensing

A method of detecting a presence and/or concentration of a marker, e.g., a marker, in a liquid, e.g., a liquid, is disclosed. The method comprises: contacting the liquid with a sensor having an immobilized affinity moiety interacting with the marker and being configured to generate a detectable signal responsively to the interaction. The method further comprises washing the liquid off the sensor, and detecting the presence and/or concentration of the marker based on a detectable signal received from the sensor within a time-window beginning a predetermined time period after a beginning time of the washing.

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Rishon-LeZion, Israel

Marina Zverzhinetsky