Mitsubishi Tanabe Pharma Corporation

Mariko Oi

Yasunori Moritani

Yasunori Tsuboi

Koichi Tanimoto

Kimihiro Shirai

Pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of formula [I]: wherein Rand Rare the same or different and each is an optionally substituted aryl group, etc., 

Pyrazolo[1,5-a] pyrimidine compounds as CB1 receptor antagonist

The present invention relates to a novel pyrazolo[1,5-a]pyrimidine compound of the formula [I]: wherein Rand Rare the same or different and an optionally substituted aryl group etc.  

Pyrazolo[1,5-A]pyrimidine compounds

The present invention provides a pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of the following formula [I]: in which Rand Rare the same or different and each an optionally substituted aryl group etc, Ris hydrogen atom, an alkyl group etc, E is a group of the formula: &#x2014;C(&#x2550;O)&#x2014; or &#x2014;SO&#x2014;, R is a group of the following formula [i], [ii]or [iii] etc: Ring A is (a) a Ccycloalkyl group optionally fused to a benzene ring or (b) a benzene ring, Q is a single bond or a methylene group, Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom etc, Ris an alkyl group optionally substituted by an alkylthio group, Ris hydrogen atom, an alkyl group etc, one of Rand Ris an alkyl group etc, and the other is hydrogen atom, an alkyl group etc, or a pharmaceutically acceptable salt thereof. 

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Osaka, Japan

Mariko Oi