Pola Chemical Industries, Inc.

Mariko Harada

Takayuki Namiki

Naoki Hiyama

Masayuki Yuasa

Yukio Kawazu

Kenichi Kishii

Masashi Tamai

Satoshi Ichinomiya

Takako Takakuwa

Mayumi Sugio

Tomoaki Yahiro

Norio Funayama

Kyoko Taneda

Masato Inazu

Tomoko Masuda

A narcotic antagonist comprising, as its active component, a compound represented by the following formula (1) or a physiologically acceptable salt thereof: wherein each of R.sup.1 and R.sup.2, which may be identical to or different from each other, represents a hydrogen atom or a halogen atom; R.sup.3 represents a hydrogen atom, an alkyl group, or an acyl group; R.sup.4 represents a hydrogen atom, an alkyl group, an acyl group, an alkylsulfonyl group, or a carboxyl group which may be esterified; Ar represents a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxyl group, a nitro group, an amino group, an alkylamino group, and a hydroxyl group or Ar represents a monocyclic aromatic heterocyclic ring having a nitrogen atom; m represents a number of 1 to 5 inclusive; and n represents a number of 0 to 5 inclusive. Also, a medicament for the prevention and treatment of narcotic dependence is provided. The medicament is effective in the prevention and treatment of narcosic dependence due to cocaine, etc.

Narcotic antagonist

The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.

Pyrrolopyrazolopyrimidine compound and medicine comprising the same as

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Yokohama, Japan

Mariko Harada