3-D Matrix, Ltd.

Marika G Rioult

Eun Seok Gil

Elton Aleksi

Naoki Yamamoto

Karl Patrick Gilbert

Keiji Nagano

Yuya Hasegawa

Toshiro Kiyofuji

Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.

Sterilization of self-assembling peptides by irradiation

Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.

Self-assembling peptides comprising non-Ionic polar amino acids

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Cambridge, MA, United States of America

Marika G Rioult