Janssen Vaccines & Prevention B.v.

Massachusetts Institute of Technology

Genmab A+s

Marijn Van Der Neut Kolfschoten

Darrell J Irvine

Ronald Vogels

Ron Weiss

Ely Blanton Porter

Mariane Bandeira Melo

Tasuku Kitada

Paul Parren

Janine Schuurman

Jan Van De Winkel

Aran Frank Labrijn

Tom Vink

Robert H E Friesen

Constantin Adrian Apetri

Rob Aalberse

Ingrid Van Den Nieuwenhof

Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.

Methods and compositions for heterologous repRNA immunizations

The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

Stable IgG4 antibodies

The disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to Hepatitis B viruses, and have a broad neutralizing activity against such Hepatitis B viruses. The disclosure further provides nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of Hepatitis B.

Human binding molecules capable of binding to and neutralizing hepatitis B viruses and uses thereof

Growing community of inventors

Amsterdam, Netherlands

Marijn Van Der Neut Kolfschoten