Janssen Vaccines & Prevention B.v.

Marija Vujadinovic

Jort Vellinga

Taco Gilles Uil

Jerôme Hubertina Henricus Victor Custers

Jerôme H H V Custers

Koen Oosterhuis

Esmerelda Van Der Helm

Esmeralda Van Der Helm

Jerôme HHV Custers

The present invention relates to novel vaccines against Human papillomavirus (HPV) infections, based on recombinant capsid-display adenovirus vectors. Described are capsid modified replication deficient adenovirus particles encoding and displaying multiple HPV L2 antigenic fragments, via a minor capsid protein IX, and their use for eliciting an immune response in order to provide protection against infections from multiple HPV types.

HPV vaccines

The present invention relates to novel vaccines against malaria infections, based on recombinant adenovirus vectors. Described are capsid modified replication deficient adenovirus particle encoding and displaying circumsporozoite (CS) protein NANP-repeats (CS) from a malaria-causing parasite, preferably, via a minor capsid protein IX and encoding a heterologous protein as a transgene. In a particular embodiment, said replication incompetent vectors of rare serotypes such as human adenovirus 35 (HAdV35) and human adenovirus 26 (HAdV26) comprise nucleic acid encoding the CS protein, as a transgene, from a malaria-causing parasite and encoding and displaying the NANP-repeat from a malaria-causing parasite (1) directly fused to the protein IX, (2) fused to protein IX via a flexible linker or (3) an alpha-helical viral origin spacer SP1 to ensure both humoral and cellular responses against the selected antigens.

Adenovirus based malaria vaccine encoding and displaying a malaria antigen

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Leiden, Netherlands

Marija Vujadinovic