Impossible Foods Inc.

Alx Oncology Inc.

Marija Vrljic

Patrick O'Reilly Brown

Ranjani Varadan

Sergey Solomatin

Michael Eisen

Celeste Holz-Schietinger

Rachel Fraser

Jessica Karr

Jaume Pons

Bang Janet Sim

Laura Deming

Corey Goodman

Patrick O'reilly Brown

The present application provides activatable antibodies comprising an antibody comprising an antigen-binding domain (ABD), wherein the ABD comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the N-terminus of the VH is fused to a first polypeptide shield moiety (S1), and the N-terminus of the VL is fused to a second polypeptide shield moiety (S2), wherein S1 comprises a first disease-sensing releasable moiety (DS1) and/or S2 comprises a second disease-sensing releasable moiety (DS2), wherein association of S1 with S2 blocks binding of the ABD to its target, and wherein the ABD does not specifically bind to S1, S2, or association thereof. Composition, methods of treatment using the activatable antibodies, and methods of preparation thereof are further provided.

Activatable antibodies and methods of use thereof

Methods and compositions for the production of non-meat consumable products are described herein. A meat substitute is described which is constructed from a muscle analog, a fat analog, and a connective tissue analog.

Methods and compositions for consumables

Disclosed herein are improved methods and compositions which more accurately replicate the characteristics that consumers value in the preparation and consumption of meat and which overcome the shortcomings and drawbacks of current meat substitutes.

Growing community of inventors

San Mateo, CA, United States of America

Marija Vrljic