Universitat Basel

Marija Plodinec

Marko Loparic

Roderick Lim

Ellen Obermann

Christian Räz

Philipp Oertle

Pascal Alexander Oehler

Leon Camenzind

Roderick Y H Lim

Christian Raez

Pascal Oehler

Roderick Yh Lim

Christian RÄZ

The invention relates to a method for classifying a tissue sample obtained from mammary carcinoma. The method comprises determining a stiffness value for each of a plurality of points on said tissue sample, resulting in a stiffness distribution, and assigning said sample to a breast cancer subtype and nodal status based on said stiffness distribution.

Nanomechanical profiling of breast cancer molecular subtypes

The present invention relates to a method for controlling a scanning probe microscope having a probe () with a tip () for interacting with a sample (), and a nanoscanner () for retaining the sample () or the probe (), comprising the steps of monitoring the extension of the piezo element () along a first direction (R) along which the tip () is moved towards the sample (), and adjusting the level of the probe () along the first direction (R) by means of an additional actuator (), when the nanoscanner () exhibits an extension below or above a threshold value. The invention further relates to a device () for controlling a scanning probe microscope.

Method and device for controlling a scanning probe microscope

The present invention relates to a method for classifying a tissue biopsy sample obtained from a tumor, comprising determining a plurality of stiffness values for said sample by measuring a plurality of points on the sample with a spatial resolution of at least 100 &#x3bc;m and assigning the sample to a probability of malignancy. A sample showing a unimodal stiffness distribution is assigned to a high probability of being non-malignant, and a sample showing an at least bimodal stiffness distribution is assigned to a high probability of being malignant, wherein said stiffness distribution is characterized by a first peak exhibiting an at least two-fold higher stiffness value than a second peak. The present invention further relates to a system for classifying a tumor tissue biopsy sample.

Method for staging cancer progression by AFM

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Basel, Switzerland

Marija Plodinec